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Diffusion-weighted magnetic resonance imaging and ultrasound evaluation of choroidal melanomas after proton-beam therapy

  • DIAGNOSTIC IMAGING IN ONCOLOGY
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Abstract

Purpose

This study was undertaken to compare the ultrasound and magnetic resonance imaging parameters of ocular melanoma and to assess their variation after proton-beam therapy.

Materials and methods

Fifteen choroidal melanoma patients treated with proton-beam therapy were enroled in the study. All patients underwent ophthalmologic evaluations, ultrasound, conventional magnetic resonance (MR) imaging and diffusion-weighted MR imaging before the start of therapy and 3 and 6 months after therapy. Basal diameters, thickness, internal reflectivity, tumour volumes and apparent diffusion coefficient (ADC) values of ocular melanomas were measured at each examination. Correlations between internal reflectivity and ADC were investigated.

Results

No significant changes were seen in tumour diameters and tumour height as assessed by B-scan and A-scan, respectively. Significant increase in mean tumour internal reflectivity was detected at 6 months (baseline 35 % ± 11; 6 months 48 % ± 8, Tukey–Kramer p = 0.005). On MRI, compared to baseline (mean 547 ± 262 mm3), a significant reduction in volume was seen at 6 months (Tukey–Kramer p = 0.045) (mean volume 339 ± 170 mm3, mean reduction 38 %). A significant increase in ADC (baseline 1,002 ± 109 mm2/s) was detected both at 3 and 6 months after proton therapy (respectively, 1,454 ± 90 and 1,833 ± 261 mm2/s, both p < 0.001).

Conclusions

By MRI, in particular by ADC assessment, it is possible to detect early variations in melanoma treated by proton-beam therapy. This examination could be used together with ultrasound in the follow-up of this treatment.

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Conflict of interest

The authors declare no conflict of interest.

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Authors and Affiliations

  1. Department of Ophthalmology, University of Catania, Via S. Sofia 78, 95124, Catania, Italy

    Andrea Russo, Antonio Longo, Teresio Avitabile, Maurizio Giacinto Uva, Livio Marco Franco, Vincenza Bonfiglio & Michele Reibaldi

  2. Department of Ophthalmology, University of Ancona, Ancona, Italy

    Cesare Mariotti

  3. Department of Radiology, University of Catania, Catania, Italy

    Pietro Valerio Foti, Pietro Milone & Giovanni Carlo Ettorre

  4. Department Gian Filippo Ingrassia, Unità di BioMedicina Molecolare Genomica e dei Sistemi Complessi, Genetica, Biologia Computazionale, University of Catania, Catania, Italy

    Marco Ragusa & Michele Purrello

  5. Department Gian Filippo Ingrassia, Unità di Anatomia Patologica, University of Catania, Catania, Italy

    Rosario Caltabiano & Lidia Puzzo

Authors
  1. Andrea Russo
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  2. Cesare Mariotti
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  3. Antonio Longo
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  4. Pietro Valerio Foti
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  6. Maurizio Giacinto Uva
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  8. Vincenza Bonfiglio
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  9. Pietro Milone
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  13. Rosario Caltabiano
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  14. Lidia Puzzo
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  15. Michele Reibaldi
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Correspondence to Andrea Russo.

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Russo, A., Mariotti, C., Longo, A. et al. Diffusion-weighted magnetic resonance imaging and ultrasound evaluation of choroidal melanomas after proton-beam therapy. Radiol med 120, 634–640 (2015). https://doi.org/10.1007/s11547-015-0509-1

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  • DOI: https://doi.org/10.1007/s11547-015-0509-1

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