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Clinical applications of dynamic susceptibility contrast perfusion-weighted MR imaging in brain tumours

Impiego clinico della sequenza RM di perfusione con tecnica dinamica contrastografica nei tumori cerebrali

  • Neuroradiology / Neuroradiologia
  • Published:
La radiologia medica Aims and scope Submit manuscript

Abstract

Magnetic resonance imaging (MRI) with a dynamic susceptibility contrast perfusion-weighted imaging (DSC-PWI) sequence to study brain tumours provides information on the haemodynamic characteristics of the neoplastic tissue. Brain perfusion maps and calculation of perfusion parameters, such as relative cerebral blood flow (rCBF), relative cerebral blood volume (rCBV) and mean transit time (MTT) allow assessment of vascularity and angiogenesis within tumours of the central nervous system (CNS), thus providing additional information to conventional MRI sequences. Although DSC-PWI has long been used, its clinical use in the study of brain tumours in daily clinical practice is still to be defined. The aim of this review was to analyse the application of perfusion MRI in the study of brain tumours by summarising our personal experience and the main results reported in the literature.

Riassunto

L’utilizzo della sequenza dinamica di perfusione con mezzo di contrasto (DSC-PWI) in risonanza magnetica (RM) nello studio dei tumori cerebrali fornisce informazioni sulle caratteristiche emodinamiche del tessuto neoplastico. L’elaborazione delle mappe di perfusione cerebrale ed il calcolo dei parametri di perfusione, come il flusso ematico cerebrale relativo (rCBF), il volume ematico cerebrale relativo (rCBV) ed il tempo di transito medio (MTT), consentono di studiare la vascolarizzazione ed i processi angiogenetici presenti nel contesto dei tumori del sistema nervoso centrale (CNS), fornendo informazioni aggiuntive alle sequenze RM convenzionali. Nonostante abbia un impiego diagnostico diffuso, l’esatto ruolo assunto dalla metodica nello studio delle neoplasie cerebrali, nella pratica clinica quotidiana, non è esattamente definito. Lo scopo di questa revisione è quello di analizzare le applicazioni della sequenza di perfusione nello studio dei tumori cerebrali riassumendo l’esperienza personale ed i principali risultati emergenti dalla letteratura.

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Authors and Affiliations

  1. NESMOS Department, Neuroradiology Faculty, Sant’ Andrea Hospital, La Sapienza University, Via di Grottarossa 1035, 00189, Rome, Italy

    A. Romano, M. C. Rossi Espagnet, L. F. Calabria, V. Coppola, L. Figà Talamanca, V. Cipriani, L. M. Fantozzi & A. Bozzao

  2. Radiotherapy Department, Sant’Andrea Hospital, Rome, Italy

    G. Minniti

  3. IRCSS San Raffaele Pisana, Rome, Italy

    A. Romano & A. Pierallini

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  1. A. Romano
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  2. M. C. Rossi Espagnet
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Correspondence to M. C. Rossi Espagnet.

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Romano, A., Rossi Espagnet, M.C., Calabria, L.F. et al. Clinical applications of dynamic susceptibility contrast perfusion-weighted MR imaging in brain tumours. Radiol med 117, 445–460 (2012). https://doi.org/10.1007/s11547-011-0715-4

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  • DOI: https://doi.org/10.1007/s11547-011-0715-4

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