La radiologia medica

, Volume 116, Issue 7, pp 1014–1026 | Cite as

Diagnostic accuracy of 64-slice computed tomography coronary angiography in a large population of patients without revascularisation: registry data in NSTEMI acute coronary syndrome and influence of gender and risk factors

  • E. Maffei
  • C. Martini
  • C. Tedeschi
  • P. Spagnolo
  • A. Zuccarelli
  • T. Arcadi
  • A. Guaricci
  • S. Seitun
  • A. C. Weustink
  • N. R. Mollet
  • F. CademartiriEmail author
Cardiac Radiology / Cardioradiologia



This study sought to evaluate the diagnostic accuracy of computed tomography coronary angiography (CTCA) for detecting significant coronary artery stenosis (≥50% lumen reduction) compared with conventional coronary angiography (CAG) in non-ST-elevation myocardial infarction-acute coronary syndrome (NSTEMI-ACS) and in subgroups selected by gender and number of risk factors (RF).

Materials and methods

We selected from a population of 1,500 patients in a multicentre registry with NSTEMI-ACS who had undergone CTCA and CAG, (n=237; 187 men, mean age 63±10 years). Diagnostic accuracy and likelihood ratios (LR) of CTCA were assessed against CAG in the total population and subgroups (men, women: 0 RF = absence of RF, 1–2 RF = presence of one or two RF, >2 RF = presence of more than two RF).


The prevalence of obstructive disease was 53%. In the per-patient analysis, sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV) of CTCA were 100% (men 100%; women 100%; 0 RF 100%; 1–2 RF 100%; >2 RF 100%), 95% (men 98%; women 50%; 0 RF NA% (NA, not assessable); 1–2 RF 96%; >2 RF 96%), 95% (men 98%; women 91%; 0 RF 91%; 1–2 RF 96%; >2 RF 96%), 100% (men 100%; women 100%; 0 RF NV%; 1–2 RF 100%; >2 RF 100%), respectively. The per-segment analysis showed a reduction in PPV (ranging between 56% and 67%). The per-patient LR+ ranged between 18 and 27, whereas LR-were always 0. We observed no significant differences in diagnostic accuracy between subgroups.


CTCA is a reliable diagnostic modality with high sensitivity and NPV in NSTEMI-ACS patients who are not candidates for early revascularisation, regardless of gender and number of risk factors.


CT coronary angiography Conventional coronary angiography Acute coronary syndrome NSTEMI Risk factors Diagnostic accuracy Registry 

Accuratezza diagnostica dell’angiografia coronarica con tomografia computerizzata in una ampia popolazione di pazienti non rivascolarizzati: dati di registro nella sindrome coronarica acuta NSTEMI ed influenza del genere e dei fattori di rischio



Scopo del nostro lavoro è stato valutare l’accuratezza diagnostica dell’angiografia coronarica non invasiva con tomografia computerizzata (CTCA) nell’individuazione delle stenosi coronariche significative (riduzione del lume coronarico ≥50%) confrontata con la coronarografia convenzionale (CAG) nella sindrome coronarica acuta senza elevazione del tratto ST (ACS-NSTEMI) e nelle sue sottopopolazioni per genere e numero di fattori di rischio (FDR).

Materiali e metodi

Da una popolazione di 1500 pazienti appartenenti ad un registro multicentrico sono stati selezionati i pazienti con ACS-NSTEMI (237, 187 maschi, età media 63±10 anni) sottoposti a CTCA e CAG. Sono state calcolate l’accuratezza diagnostica e i quozienti di probabilità (LR) per la popolazione totale, e nei sottogruppi (maschi, femmine, 0RF=assenza di FDR, 1–2RF=presenza di 1 o 2 FDR, >2RF=presenza di più di 2 FDR).


La prevalenza di malattia ostruttiva nella popolazione era del 53%. Nell’analisi per paziente la sensibilità, specificità, valore predittivo positivo e negativo della CTCA sono risultati 100% (maschi 100%; femmine 100%; 0RF 100%; 1–2RF 100%; >2RF 100%), 95% (maschi 98%; femmine 50%; 0RF NV% (NV, non valutabile); 1–2RF 96%; >2RF 96%), 95% (maschi 98%; femmine 91%; 0RF 91%; 1–2RF 96%; >2RF 96%), 100% (maschi 100%; femmine 100%; 0RF NV%; 1–2RF 100%; >2RF 100%), rispettivamente. Nell’analisi per segmento si è osservato un deterioramento del valore predittivo positivo (valori compresi tra 56% e 67%). I LR+ per paziente nelle popolazioni sono risultati compresi tra 18 e 27, mentre i LR-sono risultati sempre pari a 0. Non sono state osservate differenze significative di accuratezza diagnostica tra le sottopopolazioni.


La CTCA è una metodica diagnostica affidabile sia per l’elevata sensibilità che per l’elevato valore predittivo negativo nei pazienti con ACS-NSTEMI non candidati ad immediata rivascolarizzazione, indipendentemente dal genere e dal numero di fattori di rischio.

Parole chiave

Angiografia coronarica TC Angiografia coronarica convenzionale Sindrome coronarica acuta NSTEMI Fattori di rischio Accuratezza diagnostica Registro 


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Copyright information

© Springer-Verlag Italia 2011

Authors and Affiliations

  • E. Maffei
    • 1
  • C. Martini
    • 1
    • 2
  • C. Tedeschi
    • 3
  • P. Spagnolo
    • 4
  • A. Zuccarelli
    • 5
  • T. Arcadi
    • 6
  • A. Guaricci
    • 7
  • S. Seitun
    • 8
  • A. C. Weustink
    • 2
  • N. R. Mollet
    • 2
  • F. Cademartiri
    • 1
    • 2
    Email author
  1. 1.Dipartimento di Radiologia e del Cardio-PolmonareAzienda Ospedaliero-Universitaria di ParmaParmaItaly
  2. 2.Dipartimento di Radiologia e CardiologiaErasmus Medical CenterRotterdamThe Netherlands
  3. 3.Dipartimento di Radiologia e CardiologiaOspedale San GennaroNapoliItaly
  4. 4.CPC — Centro Prevenzione CardiovascolareOspedale San RaffaeleMilanoItaly
  5. 5.Dipartimento di Radiologia e CardiologiaAzienda ASLCarraraItaly
  6. 6.Dipartimento di RadiologiaUniversità di MessinaMessinaItaly
  7. 7.Dipartimento di CardiologiaUniversità di FoggiaFoggiaItaly
  8. 8.Dipartimento di RadiologiaAzienda Ospedaliero-Universitaria “San Martino”GenovaItaly

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