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High-resolution computed tomography in the diagnosis and follow-up of idiopathic pulmonary fibrosis

La tomografia computerizzata ad alta risoluzione nella diagnosi e nella valutazione evolutiva della fibrosi polmonare idiopatica

La radiologia medica volume 115, pages 526–538 (2010)Cite this article

Abstract

Idiopathic pulmonary fibrosis (IPF) is the most common interstitial lung disease and is associated with a fatal prognosis. Familiarity with the typical appearances of IPF on high-resolution computed tomography (HRCT) is important, as in the appropriate clinical setting, it is often sufficient for establishing a confident diagnosis of IPF without the need for surgical biopsy. Moreover, HRCT can provide important prognostic information in IPF. This is noteworthy, as the course of IPF is variable, and many patients develop complications leading to respiratory failure and death. The purpose of this paper is to review the progress made towards a better understanding of the HRCT patterns of IPF.

Riassunto

La fibrosi polmonare idiopatica (idiopathic pulmonary fibrosis, IPF) è la più comune interstiziopatia ed è associata ad una prognosi infausta. È importante avere famigliarità con le tipiche alterazioni della IPF alla tomografia computerizzata ad alta risoluzione (highresolution computer tomography, HRCT), poiché queste, in combinazione con un profilo clinico compatibile, sono spesso sufficienti per ottenere la diagnosi di IPF senza il bisogno di ricorrere alla biopsia chirurgica. Inoltre, la HRCT può fornire importanti informazioni prognostiche per i pazienti con IPF. Questo è importante in considerazione del comportamento variabile della malattia, con molti pazienti in cui si osserva l’insorgenza di complicanze che conducono all’insufficienza respiratoria e alla morte. L’obiettivo di questo articolo è quello di riassumere i recenti progressi fatti verso una migliore comprensione degli aspetti sopra-riportati della IPF.

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Affiliations

  1. Dipartimento di Scienze Cliniche, Sezione di Diagnostica per Immagini, Università degli Studi di Parma, Parma, Italy

    N. Sverzellati & M. De Filippo

  2. Dottorato di Scienze Pneumo-Cardio-Toraciche di Interesse Medico e Chirurgico, Università di Bologna, Bologna, Italy

    T. Bartalena

  3. U.O. Radiologia IRST, Istituto Scientifico Romagnolo per lo Studio e la cura dei Tumori, Meldola-Forlì, Italy

    S. Piciucchi

  4. Radiologia III — Pol. S.Orsola-Malpighi, Bologna, Italy

    M. Zompatori

  5. Padiglione Barbieri, Sezione di Diagnostica per Immagini, Azienda Ospedaliero-Universitaria di Parma, 43100, Parma, Italy

    N. Sverzellati

Authors
  1. N. Sverzellati
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  2. M. De Filippo
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  3. T. Bartalena
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  4. S. Piciucchi
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  5. M. Zompatori
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Correspondence to N. Sverzellati.

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Sverzellati, N., De Filippo, M., Bartalena, T. et al. High-resolution computed tomography in the diagnosis and follow-up of idiopathic pulmonary fibrosis. Radiol med 115, 526–538 (2010). https://doi.org/10.1007/s11547-010-0512-5

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  • DOI: https://doi.org/10.1007/s11547-010-0512-5

Keywords

  • Idiopathic pulmonary fibrosis
  • Usual interstitial pneumonia
  • High-resolution computed tomography
  • Complications

Parole chiave

  • Fibrosi polmonare idiopatica
  • Polmonite interstiziale usuale
  • Tomografia computerizzata ad alta risoluzione
  • Complicanze