Skip to main content

Evaluation of Genotoxic and Apoptotic Effects of Sprouted Potato

Abstract

Potato is among the foods we consume frequently in our daily life. The harmful effects of consuming sprouted potatoes on our health are mentioned. Sprouted potato contains higher levels of glycoalkaloids, which can have toxic effects in humans and animals. Discarding the sprouts, skin and green parts from tubers may help reduce risk of toxicity. In this study, we aimed to determine whether the flesh part of the sprouted potato has genotoxic and apoptotic effects. Phenolic compounds were determined by HPLC method in sprouted and unsprouted potato extracts. The genotoxicity and apoptosis effects of sprouted and unsprouted potato extracts at various concentrations were investigated in human peripheral lymphocytes by comet assay and DNA ladder assay. The phenolic compounds of chlorogenic acid, vanilin, caffeic acid and o-coumaric acid were detected at a higher level in the sprouted potato than in the unsprouted potato, while only p-hydroxybenzoic acid was determined at a lower level. As a result of our research, we detect that the sprouted potato extract did not cause statistically significant DNA damage in human lymphocytes (p > 0.05), and we could not detect DNA fragment images of human peripheral lymphocytes in the DNA ladder assay. It was concluded that consuming sprouted potatoes (flesh part) by discarding the sprouts, eyes, green skin, and bruised parts may help reduce the glycoalkaloid-induced genotoxicity and apoptosis.

This is a preview of subscription content, access via your institution.

Fig. 1
Fig. 2
Fig. 3

References

Download references

Acknowledgements

The authors acknowledge the members of the Innovative Technologies Application and Research Center of Suleyman Demirel University, the Medical Biology of Suleyman Demirel University Faculty of Medicine for their support in preparing this work and for making it possible.

Author information

Authors and Affiliations

Authors

Contributions

All the authors participated in this study including data interpretation and manuscript preparation. All the authors took full responsibility for the manuscript.

Corresponding author

Correspondence to Okan Sancer.

Ethics declarations

Ethics Approval

This study was approved by Isparta Süleyman Demirel University Medical Faculty Ethics Committee (No: 7/90).

Conflict of Interest

The authors declare no competing interests.

Additional information

Publisher’s Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Rights and permissions

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

Sancer, O., Şahin, U., Ateş, M. et al. Evaluation of Genotoxic and Apoptotic Effects of Sprouted Potato. Potato Res. (2022). https://doi.org/10.1007/s11540-022-09560-1

Download citation

  • Received:

  • Accepted:

  • Published:

  • DOI: https://doi.org/10.1007/s11540-022-09560-1

Keywords

  • Apoptosis
  • Comet assay
  • Phenolic compounds
  • Potato