## Abstract

We propose a mathematical model to describe enzyme-based tissue degradation in cancer therapies. The proposed model combines the poroelastic theory of mixtures with the transport of enzymes or drugs in the extracellular space. The effect of the matrix-degrading enzymes on the tissue composition and its mechanical response are accounted for. Numerical simulations in 1D, 2D and axisymmetric (3D) configurations show how an injection of matrix-degrading enzymes alters the porosity of a biological tissue. We eventually exhibit numerically the main consequences of a matrix-degrading enzyme pretreatment in the framework of chemotherapy: the removal of the diffusive hindrance to the penetration of therapeutic molecules in tumors and the reduction of interstitial fluid pressure which improves transcapillary transport. Both effects are consistent with previous biological observations.

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## Acknowledgements

The authors thank Professor E. Signori for her advices and fruitful discussions on the experimental features of drug injection in tumor and muscles. M.D. is partly granted by “Université Franco-Italienne,” Project VINCI C2-25. M.D. and C.P. are partly granted by the Plan Cancer DYNAMO (Inserm 9749) and Plan Cancer NUMEP (Inserm 11099). This study has been carried out within the scope of the European Associate Lab EBAM and the Inria Associate Team Num4SEP.

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## Appendix A: Formulation of the Model in \(\varOmega _0\) in the General Case

### Appendix A: Formulation of the Model in \(\varOmega _0\) in the General Case

The calculus in the general case gives the final system of Eq. (76). Recall that matrix *B* is defined as the inverse of matrix *A* given by (46). As,

we kept the notation *B* to refer to \(B({\overline{\mathbf{u }}})\) in system (76). Note that we equally dropped bars on the dimensionless variables but kept them on the dimensionless parameters. Let us denote

The equivalent system in \(\varOmega _0\) in dimensionless form reads

where we get (76a) from Assumption 1, (76b) from Eq. (20), (76c) from (15), (76d) from (24), (76g) from (28), (76f) from (13a) and (76e) from (13b), using (50), (51) and (52).

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Deville, M., Natalini, R. & Poignard, C. A Continuum Mechanics Model of Enzyme-Based Tissue Degradation in Cancer Therapies.
*Bull Math Biol* **80, **3184–3226 (2018). https://doi.org/10.1007/s11538-018-0515-2

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DOI: https://doi.org/10.1007/s11538-018-0515-2

### Keywords

- Mathematical biology
- Poroelasticity
- ECM degradation
- Interstitial fluid pressure
- Drug distribution in tissue

### Mathematics Subject Classification

- 65M06
- 65M12
- 92C37