Toward a Unique Definition of the Mutation Rate
- 337 Downloads
In around 1943, while writing a classic paper with Luria, Delbrück envisioned two kinds of mutation rates: One was expressed as mutations per bacterium per unit time, the other as mutations per bacterium per division cycle. Due to minor mathematical errors, the precise connection between the two concepts remained elusive for Delbrück. As a result, researchers and educators alike are still grappling with the definition of the mutation rate. Within the context of microbial mutation, the current author proposes an idealized model to bring new clarity to the distinction between the two forms of the mutation rate that Delbrück once attempted to define and characterize. The paper also critiques two incorrect estimators of mutation rates and brings to light two important yet unexplored “invariance” hypotheses about mutation rates.
KeywordsMutation rate Luria–Delbrück protocol Cell generation time
The author expresses his gratitude to a referee for numerous thoughtful suggestions that substantially enhanced the paper’s readability.
- Griffiths AJF, Miller JH, Suzuki DT, Lewontin RC, Gelbart W (2000) An introduction to genetic analysis, 7th edn. W.H. Freeman and Company, New YorkGoogle Scholar
- Luria SE (1984) A slot machine. A broken test tuber. Harper & Row, New YorkGoogle Scholar
- Luria SE, Delbrück M (1943) Mutations of bacteria from virus sensitivity to virus resistance. Genetics 28:491–511Google Scholar
- Russell PJ (2006) iGenetics. A Mendelian approach. Benjamin Cummings, Menlo ParkGoogle Scholar
- Snyder L, Champness W (2007) Molecular genetics of bacteria, 3rd edn. ASM Press, WashingtonGoogle Scholar
- Zamenhof S (1946) Discussion of Shapiro’s paper. Cold Spring Harb Symp Quant Biol 11:235Google Scholar
- Zheng Q (2003) Mathematical issues arising from the directed mutation controversy. Genetics 164:373–379Google Scholar