Bulletin of Mathematical Biology

, Volume 79, Issue 1, pp 36–62 | Cite as

Antimicrobial Stewardship and Environmental Decontamination for the Control of Clostridium difficile Transmission in Healthcare Settings

  • Jason Bintz
  • Suzanne LenhartEmail author
  • Cristina Lanzas
Original Article


We implement an agent-based model for Clostridium difficile transmission in hospitals that accounts for several processes and individual factors including environmental and antibiotic heterogeneity in order to evaluate the efficacy of various control measures aimed at reducing environmental contamination and mitigating the effects of antibiotic use on transmission. In particular, we account for local contamination levels that contribute to the probability of colonization and we account for both the number and type of antibiotic treatments given to patients. Simulations illustrate the relative efficacy of several strategies for the reduction of nosocomial colonizations and nosocomial diseases.


Clostridium difficile Control Agent-based model 



The work of all the authors was partially supported by the National Institute of Mathematical and Biological Synthesis (NIMBioS), an Institute sponsored by National Science Foundation, the US Department of Homeland Security, and the US Department Agriculture through NSF Awards #EF-0832858 and #DBI-1300426, with additional support from University of Tennessee, Knoxville. This work was also supported by the joint NSF/NIGMS Mathematical Biology Program through NIH award R01GM113239. Lenhart’s work is also partially supported by the University of Tennessee Center for Business and Economic Research.


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Copyright information

© Society for Mathematical Biology 2016

Authors and Affiliations

  1. 1.Department of MathematicsHoughton CollegeHoughtonUSA
  2. 2.Department of MathematicsUniversity of TennesseeKnoxvilleUSA
  3. 3.Department of Population Health and PathobiologyNorth Carolina State UniversityRaleighUSA

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