Modeling Intercellular Transfer of Biomolecules Through Tunneling Nanotubes
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Tunneling nanotubes (TNTs) have previosly been observed as long and thin transient structures forming between cells and intercellular protein transfer through them has been experimentally verified. It is hypothesized that this may be a physiologically important means of cell–cell communication. This paper attempts to give a simple model for the rates of transfer of molecules across these TNTs at different distances. We describe the transfer of both cytosolic and membrane bound molecules between neighboring populations of cells and argue how the lifetime of the TNT, the diffusion rate, distance between cells, and the size of the molecules may affect their transfer. The model described makes certain predictions and opens a number of questions to be explored experimentally.
KeywordsDiffusion Length Donor Cell Protein Transfer Cytoplasmic Protein Recipient Cell
- Baba, E., et al. (2001). Functional CD4 T cells after intercellular molecular transfer of 0X40 ligand. J. Immunol., 167(2), 875–883. Google Scholar
- Denzer, K., Kleijmeer, M. J., Heijnen, H. F., Stoorvogel, W., & Geuze, H. J. (2000). Exosome: from internal vesicle of the multivesicular body to intercellular signaling device. J. Cell Sci., 113(19), 3365–3374. Google Scholar
- Guescini, M., et al. (2012). Microvesicle and tunneling nanotube mediated intercellular transfer of g-protein coupled receptors in cell cultures. In Experimental cell research. Google Scholar