Bulletin of Mathematical Biology

, Volume 74, Issue 12, pp 2861–2874 | Cite as

The Shuttling Scaffold Model for Prevention of Yeast Pheromone Pathway Misactivation

  • Aditya P. Singh
  • Erik Andries
  • Jeremy S. Edwards
  • Stanly Steinberg
Original Article


The molecular scaffold in the yeast pheromone pathway, Ste5, shuttles continuously between the nucleus and the cytoplasm. Ste5 undergoes oligomerization reaction in the nucleus. Upon pheromone stimulation, the Ste5 dimer is rapidly exported out of the nucleus and recruited to the plasma membrane for pathway activation. This clever device on part of the yeast cell is thought to prevent pathway misactivation at high enough levels of Ste5 in the absence of pheromone. We have built a spatiotemporal model of signaling in this pathway to describe its regulation. Our present work underscores the importance of spatial modeling of cell signaling networks to understand their control and functioning.


Active Transport Nuclear Envelope Passive Diffusion Nuclear Import Wheat Germ Agglutinin 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.



Ordinary Differential Equation


Partial Differential Equation

Supplementary material

11538_2012_9785_MOESM1_ESM.pdf (920 kb)
Appendixes A–i (PDF 920 kB)


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Copyright information

© Society for Mathematical Biology 2012

Authors and Affiliations

  • Aditya P. Singh
    • 1
  • Erik Andries
    • 2
    • 3
  • Jeremy S. Edwards
    • 4
    • 5
  • Stanly Steinberg
    • 2
  1. 1.PatialaIndia
  2. 2.Department of Mathematics and StatisticsUniversity of New MexicoAlbuquerqueUSA
  3. 3.Department of MathematicsCentral New Mexico Community CollegeAlbuquerqueUSA
  4. 4.Molecular Genetics and Microbiology, Cancer Research and Treatment CenterUniversity of New Mexico Health Sciences CenterAlbuquerqueUSA
  5. 5.Chemical and Nuclear EngineeringUniversity of New MexicoAlbuquerqueUSA

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