Targeted Oncology

, Volume 12, Issue 6, pp 833–838 | Cite as

Non-Small-Cell Lung Cancer (NSCLC) Harboring ALK Translocations: Clinical Characteristics and Management in a Real-Life Setting: a French Retrospective Analysis (GFPC 02–14 Study)

  • Jean-Bernard Auliac
  • Isabelle Monnet
  • Catherine Dubos-Arvis
  • Anne Marie Chiappa
  • Nathalie Baize
  • Suzana Bota
  • Alain Vergnenegre
  • Helene Doubre
  • Chrystele Locher
  • Acya Bizieux
  • Gilles Robinet
  • Christos Chouaid
Short Communication

Abstract

Background

Chromosomal translocations involving the anaplastic lymphoma kinase gene (ALK) are rare oncogenic events found in 3–5% of non-small-cell lung cancers (NSCLC). Limited data have been published on the management of these patients outside clinical trials.

Objective

To investigate the clinical characteristics and management of patients with NSCLC harboring ALK translocations (ALK+) in a real-life setting in France.

Methods

This multicenter, observational, retrospective study included all NSCLC patients harboring ALK translocations diagnosed in participating centers between January 2012 and December 2014. Patient data include clinical characteristics, disease management, and outcomes [progression-free survival (PFS) and overall survival (OS)].

Results

The 31 participating centers reported data on 132 patients, of whom 51% (n = 67) were male. The median age was 60.1 ± 14.5 (standard deviation) years; 89% (n = 106/119) had performance status 0/1 at diagnosis; 79% (n = 103/130) were non- or former smokers; 93% (n = 120/129) had adenocarcinomas and 74%(n = 97)/19%(n = 25)/7%(n = 10) had disease stages IV/III/I-II at diagnosis, respectively; co-mutations included EGFR (n = 2), BRAF (n  = 2), KRAS (n = 1), and HER2 (n = 1). Of the patients with stage IV NSCLC (n = 97), 96% received first-line treatment [75% chemotherapy-based, 21% ALK tyrosine kinase inhibitor (TKI)], with an associated response rate (RR), disease-control rate (DCR), and PFS of 42%, 64%, and 7.5 [95% confidence interval (CI) 5.9–9.5] months, respectively; 62% received second-line treatment (28% chemotherapy, 72% ALK TKI) with an associated RR, DCR, and PFS of 43.4%, 70%, and 4.7 (95% CI 4.0–8.1) months, respectively. The 2-year OS was 56.7% (95% CI 45.5–70.4%); median OS was not reached.

Conclusion

The results of this real-life analysis suggest that the prognosis of NSCLC patients with theALK translocation may be better than that of the overall NSCLC population, but the outcomes were poorer than those of ALK+ NSCLC patients included in clinical studies.

Notes

Compliance with Ethical Standards

Funding

The study was supported by academic grants from Lilly, Astra Zeneca, and Boehringer Ingelheim. The sponsors played no role in the design or performance of the study, data analysis, or manuscript preparation. The results belong to Groupe Français d’Oncologie Thoracique (GFPC). The data were analyzed by the GFPC statistician and interpreted by the authors.

Conflict of Interest

Jean-Bernard Auliac has received honoraria for attending scientific meetings, speaking, organizing research, or consulting from Boehringer Ingelheim, Hoffman-Roche, Lilly, and Pfizer. Helene Doubre has received honoraria for consulting from Novartis, AstraZeneca, BMS, MSD, and Boehringer Ingelheim. Christos Chouaid has received honoraria for attending scientific meetings, speaking, organizing research, or consulting from AstraZeneca, Boehringer Ingelheim, GlaxoSmithKline, Hoffman-Roche, Sanofi Aventis, Lilly, Novartis, and Amgen. All other authors declare no conflict of interest.

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Copyright information

© Springer International Publishing AG 2017

Authors and Affiliations

  • Jean-Bernard Auliac
    • 1
  • Isabelle Monnet
    • 2
  • Catherine Dubos-Arvis
    • 3
  • Anne Marie Chiappa
    • 4
  • Nathalie Baize
    • 5
  • Suzana Bota
    • 6
  • Alain Vergnenegre
    • 7
  • Helene Doubre
    • 8
  • Chrystele Locher
    • 9
  • Acya Bizieux
    • 10
  • Gilles Robinet
    • 11
  • Christos Chouaid
    • 2
  1. 1.Service de Pneumologie et Oncologie ThoraciqueCenter Hospitalier (CH) François QuesnayMantes-la-JolieFrance
  2. 2.Centre Hospitalier Intercommunal de Créteil (CHI)CréteilFrance
  3. 3.CAC CaenCaenFrance
  4. 4.CH QuimperQuimperFrance
  5. 5.Le Centre Hospitalier Universitaire (CHU) AngersAngersFrance
  6. 6.CHU RouenRouenFrance
  7. 7.CHU LimogesLimogesFrance
  8. 8.CH SuresnesSuresnesFrance
  9. 9.CH MeauxMeauxFrance
  10. 10.CH La Roche-sur-YonLa Roche-sur-YonFrance
  11. 11.CHU BrestBrestFrance

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