Targeted Oncology

, Volume 9, Issue 1, pp 1–8 | Cite as

Trends in cancer-targeted antibody–drug conjugates

Review

Abstract

Better knowledge of engineered antibodies and tumour biology has led to the development of novel targeted therapies, such as antibody–drug conjugates (ADCs). ADCs combine a monoclonal antibody, directed toward specific antigen highly expressed on the cancer cell, to potent cytotoxic drug through a stable linker. ADCs are designed to bind selectively to cancer cells and to deliver cytotoxic drugs into the cancer cell, which may preserve normal cells. ADCs should be stable and non-toxic in circulation. Upon binding to antigen, ADCs are internalized by different processes, followed by the intracellular release of an active form of the cytotoxic drug, which in turn kills the cancer cell. This technology has the potential to further improve the anticancer activity while limiting toxicity. First results from ongoing clinical trials are encouraging. Favourable pharmacokinetic profile was observed showing good stability in circulation. Clinical studies demonstrated that ADCs provide clinical efficacy with an acceptable safety profile. Objective responses and clinical benefits were demonstrated with the investigated ADCs. Major toxicities frequently associated to chemotherapy were barely or not reported with ADCs. Taken together, ADCs may become the new wave of anticancer drugs in the future.

Keywords

Monoclonal antibodies Chemotherapy Antibody–drug conjugates Linker Cancer 

Notes

Conflict of interest

The authors declare no relevant financial activities for the submitted work.

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Copyright information

© Springer-Verlag France 2013

Authors and Affiliations

  1. 1.Department of Medical OncologyInstitut CurieParisFrance
  2. 2.Department of Medical OncologyCentre Leon Bérard, CRCL INSERM 1052/CNRS 5286LyonFrance

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