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Correlation between conduction velocity and frequency analysis in patients with atrial fibrillation using high-density charge mapping

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Abstract

Spectral analysis of atrial signals has been used to identify regions of interest in atrial fibrillation (AF). However, the relationship to the atrial substrate is unclear. In this study, we compare regions with dominant frequency (DF), simultaneously determined in the left atrium (LA) by a novel noncontact mapping system using unipolar charge density signals, to the zones of slow conduction (SZ) during AF.

In 19 AF patients the conduction during AF was assessed by a validated algorithm and SZ compared to the DF and the DF ratio between the DF peak and the area under the total spectrum (DFR). The results were compared in five different regions of the LA. The reproducibility of SZ location at different time measurements was higher than for DF or DFR. The SZs are mainly confined at the anterior and posterior wall of the LA. There was no statistically significant correlation between SZ and DF or DFR across the atrium.

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Abbreviations

AF:

Atrial fibrillation

CAFE:

Complex fractionated electrogram

CD:

Charge density (C·cm−2)

CV:

Conduction velocity (m·s−1)

SZ:

Slow zone

LAT:

Local activation time (ms)

FFT:

Fast Fourrier transform

DF:

Dominant frequency (Hz)

DFR:

Dominant frequency ratio, the ratio between the DF peak and the area under the total spectrum

LA:

Left atrium

MV:

Mitral valve

LSPV:

Left pulmonary vein

LIPV:

Left inferior pulmonary vein

RSPV:

Right superior pulmonary vein

RIPV:

Right inferior pulmonary vein

LAA:

Left atrial appendage

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Author information

Authors and Affiliations

  1. HerzGefässStiftung, Klinik im Park, Zurich, Switzerland

    Lam Dang

  2. Acutus Medical, Inc, CA, 92008, Carlsbad, USA

    Nathan Angel & Min Zhu

  3. Applied Signal Processing Group, Swiss Federal Institute of Technology, Lausanne, Switzerland

    Jean-Marc Vesin

  4. Rhythmologie-Zürich AG, Zurich, Switzerland

    Christoph Scharf

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  1. Lam Dang
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  2. Nathan Angel
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  3. Min Zhu
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Correspondence to Lam Dang.

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Drs Dang and Scharf are co-founder and shareholders of Acutus Meical Inc.

Drs Angel and Zhu were previously employees and shareholders of Acutus Medical Inc.

Dr Vesin has no disclosure.

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Dang, L., Angel, N., Zhu, M. et al. Correlation between conduction velocity and frequency analysis in patients with atrial fibrillation using high-density charge mapping. Med Biol Eng Comput 60, 3081–3090 (2022). https://doi.org/10.1007/s11517-022-02659-0

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  • DOI: https://doi.org/10.1007/s11517-022-02659-0

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