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Characterization of the cylindrical electrospun nanofibrous polysulfone membrane for hemodialysis with modelling approach

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Abstract

Electrospun nanofibrous membrane (ENM) is a membrane fabricated using electrospinning technique which has considerable characteristics such as high porosity, nanometer pore size, and simple process. Although ENMs are being evaluated in various medical applications, the effectiveness for hemodialysis (HD) has not been evaluated carefully. Thus, in this study, the cylindrical electrospun nanofibrous polysulfone (CENP) membrane was fabricated and its performance in the dialysis adequacy in HD patients was evaluated.

The CENP membrane was fabricated in a tabular shape. The physical characteristics of the membrane are examined using scanning electron microscope (SEM) images and the permporometry technique. Then, its efficiency in urea and creatinine removal from the blood serum of 21 HD patients was evaluated at a low blood flow rate (BFR) of 200 ml min-1 and dialysate fluid rate (DFR) of 300 ml min-1. Afterwards, the results were modeled and optimized using artificial neural network (ANN) and genetic algorithm (GA), respectively. Finally, sensitive analysis was performed via Spearman’s rank correlation coefficient. The highest dialysis adequacy was observed in membranes with an inner diameter of 3 mm. The CENP membrane belongs to the super high-flux membrane and it could be replaced with existing commercial hollow fiber membranes.

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Acknowledgments

This article is the result of research project approved in the Environment Research Center, Research Institute for Primordial Prevention of Non-communicable Disease, Isfahan University of Medical Sciences, Isfahan, Iran.

Funding

The financial support, Research Project, # 298088 and research ethic, # IR.MUI.RESEARCH.REC.1398.371.

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Authors and Affiliations

  1. Department of Textile Engineering, Isfahan University of Technology, Isfahan, Iran

    Farideh Mohammadi

  2. Department of Environmental Health Engineering, School of Health, Isfahan University of Medical Sciences, Isfahan, Iran

    Farzaneh Mohammadi

  3. Environment Research Center, Research Institute for Primordial Prevention of Non-communicable Disease, Isfahan University of Medical Sciences, Isfahan, Iran

    Farzaneh Mohammadi

  4. Isfahan University of Medical Sciences, Isfahan, Iran

    Farzaneh Mohammadi

  5. Genetic and Environmental Adventures Research Center, school of Abarkouh Paramedicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran

    Zeynab Yavari

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  1. Farideh Mohammadi
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Farideh Mohammadi conceived of the presented idea and carried out the experiments; Farzaneh Mohammadi wrote the manuscript and developed the theory and performed the computations; Zeynab Yavari contributed to the final version of the manuscript.

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Correspondence to Farzaneh Mohammadi.

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Mohammadi, F., Mohammadi, F. & Yavari, Z. Characterization of the cylindrical electrospun nanofibrous polysulfone membrane for hemodialysis with modelling approach. Med Biol Eng Comput 59, 1629–1641 (2021). https://doi.org/10.1007/s11517-021-02404-z

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  • DOI: https://doi.org/10.1007/s11517-021-02404-z

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