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A computational analysis of the effect of supporting organs on predicted vesical pressure in stress urinary incontinence

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Abstract

Stress urinary incontinence (SUI) or urine leakage from urethra occurs due to an increase in abdominal pressure resulting from stress like a cough or jumping height. SUI is more frequent among post-menopausal women. In the absence of bladder contraction, vesical pressure exceeds urethral pressure leading to urine leakage. The main aim of this study is to utilize fluid-structure interaction techniques to model bladder and urethra computationally under an external pressure like sneezing. Both models have been developed with linear elastic properties for the bladder wall while the patient model has also been simulated utilizing the Mooney-Rivlin solid model. The results show a good agreement between the clinical data and the predicted values of the computational models, specifically the pressure at the center of the bladder. There is 1.3% difference between the predicted vesical pressure and the vesical pressure obtained from urodynamic tests. It can be concluded that the accuracy of the predicted pressure in the center of the bladder is significantly higher for the simulation assuming nonlinear material property (hyperelastic) for the bladder in comparison to the accuracy of the linear elastic model. The model is beneficial for exploring treatment solutions for SUI disorder.

3D processing of bladder deformation during abdominal pressure of a the physiological model and b the pathological model (starting from left to right and up to down, consecutively)

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Authors and Affiliations

  1. Division of Biomedical Engineering, Department of Life Science Engineering, Faculty of New Sciences and Technologies, University of Tehran, Tehran, Iran

    Mojtaba Barzegari, Bahman Vahidi & Mahtab Ebad

  2. Biomechanics Section, Department of Mechanical Engineering, KU Leuven, Leuven, Belgium

    Mojtaba Barzegari

  3. Clinical Center for Urological Disease Diagnosis and Private Clinic Specialized in Urological and Andrological Genetics, Tehran, Iran

    Mohammad Reza Safarinejad

Authors
  1. Mojtaba Barzegari
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  2. Bahman Vahidi
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  3. Mohammad Reza Safarinejad
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  4. Mahtab Ebad
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Correspondence to Bahman Vahidi.

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Barzegari, M., Vahidi, B., Safarinejad, M.R. et al. A computational analysis of the effect of supporting organs on predicted vesical pressure in stress urinary incontinence. Med Biol Eng Comput 58, 1079–1089 (2020). https://doi.org/10.1007/s11517-020-02148-2

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  • DOI: https://doi.org/10.1007/s11517-020-02148-2

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