Medical & Biological Engineering & Computing

, Volume 57, Issue 6, pp 1313–1322 | Cite as

Inducing therapeutic hypothermia via selective brain cooling: a finite element modeling analysis

  • Lu Yin
  • Hongwei Jiang
  • Weiwei Zhao
  • Hui LiEmail author
Original Article


Therapeutic hypothermia is a treatment method to reduce brain injuries after stroke, especially for cerebral ischemia. This study investigates in the temperature distribution of the head within selective brain cooling (SBC). Anatomically accurate geometries based on CT images of head and neck regions are used to develop the 3D geometry and physical model for the finite element modeling. Two cooling methods, the direct head surface cooling strategy and the combination cooling strategy of both head and neck, are evaluated to analyze the inducing hypothermia. The results show that for direct head surface cooling, the scalp and skull temperatures decrease significantly as the blood perfusion rate is constrained, but it is hard to affect the brain core temperature. To achieve a lower cerebral temperature, combination cooling strategy of both head and neck is an effective method in improving deep brain cooling. In normal condition, the cerebral temperature is reduced by about 0.12 °C in 60 min of hypothermia, while the temperature drop is approximately 0.98 °C in ischemic condition.

Graphical abstract

In this study, the 3D geometry of the head and carotid artery model based on the computed tomography (CT) were derived separately and the corresponding investigations were conducted to validate the reliability of the model. Direct head surface cooling strategy and the combination cooling strategy of both the head and neck were numerically researched.


Hypothermia Selective brain cooling Finite element modeling Neck cooling 


Funding information

The study is supported by China Postdoctoral Science Foundation (No. 2018 M640797), the open fund of Hubei key laboratory of mechanical transmission and manufacturing engineering in Wuhan University of Science and Technology (No. 2017A05), and the young researcher project funded by South China Normal University (No. 17KJ14).

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.


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Copyright information

© International Federation for Medical and Biological Engineering 2019

Authors and Affiliations

  1. 1.Shenzhen UniversityShenzhenPeople’s Republic of China
  2. 2.National Center for International Research on Green OptoelectronicsSouth China Normal UniversityGuangzhouPeople’s Republic of China

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