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Medical & Biological Engineering & Computing

, Volume 56, Issue 9, pp 1699–1713 | Cite as

Patient-specific and global convolutional neural networks for robust automatic liver tumor delineation in follow-up CT studies

  • Refael VivantiEmail author
  • Leo Joskowicz
  • Naama Lev-Cohain
  • Ariel Ephrat
  • Jacob Sosna
Original Article

Abstract

Radiological longitudinal follow-up of tumors in CT scans is essential for disease assessment and liver tumor therapy. Currently, most tumor size measurements follow the RECIST guidelines, which can be off by as much as 50%. True volumetric measurements are more accurate but require manual delineation, which is time-consuming and user-dependent. We present a convolutional neural networks (CNN) based method for robust automatic liver tumor delineation in longitudinal CT studies that uses both global and patient specific CNNs trained on a small database of delineated images. The inputs are the baseline scan and the tumor delineation, a follow-up scan, and a liver tumor global CNN voxel classifier built from radiologist-validated liver tumor delineations. The outputs are the tumor delineations in the follow-up CT scan. The baseline scan tumor delineation serves as a high-quality prior for the tumor characterization in the follow-up scans. It is used to evaluate the global CNN performance on the new case and to reliably predict failures of the global CNN on the follow-up scan. High-scoring cases are segmented with a global CNN; low-scoring cases, which are predicted to be failures of the global CNN, are segmented with a patient-specific CNN built from the baseline scan. Our experimental results on 222 tumors from 31 patients yield an average overlap error of 17% (std = 11.2) and surface distance of 2.1 mm (std = 1.8), far better than stand-alone segmentation. Importantly, the robustness of our method improved from 67% for stand-alone global CNN segmentation to 100%. Unlike other medical imaging deep learning approaches, which require large annotated training datasets, our method exploits the follow-up framework to yield accurate tumor tracking and failure detection and correction with a small training dataset.

Graphical abstract

Flow diagram of the proposed method. In the offline mode (orange), a global CNN is trained as a voxel classifier to segment liver tumor as in [31]. The online mode (blue) is used for each new case. The input is baseline scan with delineation and the follow-up CT scan to be segmented. The main novelty is the ability to predict failures by trying the system on the baseline scan and the ability to correct them using the patient-specific CNN

Keywords

Liver tumor segmentation Follow-up CT scans Longitudinal studies Deep learning Convolutional neural networks 

Notes

Acknowledgements

This work was partially supported by Grant 53681 from the Israel Ministry of Science, Technology and Space entitled: METASEG: a new medical image segmentation paradigm for clinical decision support and big data radiology.

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.

Protection of human and animal rights statement

No animals or humans were involved in this research. All scans were anonymized before delivery to the researchers.

Supplementary material

11517_2018_1803_MOESM1_ESM.docx (15 kb)
ESM 1 (DOCX 14.9 kb)

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Copyright information

© International Federation for Medical and Biological Engineering 2018

Authors and Affiliations

  • Refael Vivanti
    • 1
    Email author
  • Leo Joskowicz
    • 1
  • Naama Lev-Cohain
    • 2
  • Ariel Ephrat
    • 1
  • Jacob Sosna
    • 2
  1. 1.School of Computer Science and EngineeringThe Hebrew University of JerusalemJerusalemIsrael
  2. 2.Department of RadiologyHadassah Hebrew University Medical CenterJerusalemIsrael

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