Medical & Biological Engineering & Computing

, Volume 49, Issue 9, pp 1083–1088 | Cite as

Quantitative calculation of human melatonin suppression induced by inappropriate light at night

  • Yang Meng
  • Zhenni He
  • Jian Yin
  • Yu Zhang
  • Tianhao ZhangEmail author
Original Article


Melatonin (C13H16N2O2) has a wide range of functions in the body. When is inappropriately exposed to light at night, human circadian rhythm will be interfered and then melatonin secretion will become abnormal. For nearly three decades great progresses have been achieved in analytic action spectra and melatonin suppression by various light conditions. However, so far few articles focused on the quantitative calculation of melatonin suppression induced by light. In this article, an algorithm is established, in which all the contributions of rods, cones, and intrinsically photosensitive retinal ganglion cells are considered. Calculation results accords with the experimental data in references very well, which indicate the validity of this algorithm. This algorithm can also interpret the rule of melatonin suppression varying with light correlated color temperature very well.


Light Melatonin suppression Algorithm IpRGC Rods Cones 



We are grateful for the technical assistance from Associate Prof. X.X. Xu, the Key Laboratory of Weak Light Nonlinear Photonics, Ministry of Education, China; logistical and editorial assistance from Prof. C.P. Zhang and Vice President Prof. C.Y. Li, School of Physics, Nankai University, China.


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Copyright information

© International Federation for Medical and Biological Engineering 2011

Authors and Affiliations

  • Yang Meng
    • 1
  • Zhenni He
    • 3
  • Jian Yin
    • 2
  • Yu Zhang
    • 1
  • Tianhao Zhang
    • 1
    Email author
  1. 1.Photonics Research Center, School of PhysicsNankai UniversityTianjinChina
  2. 2.Department of Breast, Cancer HospitalTianjin Medical UniversityTianjinChina
  3. 3.Physics Experiment CenterRenai Collage of Tianjin UniversityTianjinChina

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