Frontiers in Biology

, 6:177 | Cite as

Membrane-bound O-acyltransferases (MBOATs)

  • Catherine C. Y. ChangEmail author
  • Jie Sun
  • Ta-Yuan ChangEmail author


The MBOAT enzyme family, identified in 2000, comprises 11 genes in the human genome that participate in a variety of biological processes. MBOAT enzymes contain multiple transmembrane domains and share two active site residues, histidine and asparagine. Several MBOAT members are drug targets for major human diseases, including atherosclerosis, obesity, Alzheimer disease, and viral infections. Here we review the historical aspects of MBOAT enzymes, classify them biochemically into 3 subgroups, and describe the essential features of each member.


cholesterol metabolism neutral lipid biosynthesis protein acylation membrane phospholipid remodeling atherosclerosis diabetes obesity cancer nutrient sensing 


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© Higher Education Press and Springer-Verlag Berlin Heidelberg 2011

Authors and Affiliations

  1. 1.Department of BiochemistryDartmouth Medical SchoolHanoverUSA

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