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Frontiers in Biology

, 6:328 | Cite as

The mechanism of protein kinase C regulation

  • Julhash U. Kazi
Review
  • 483 Downloads

Abstract

Protein kinase C (PKC) is a family of serine/threonine protein kinases that plays a central role in transducing extracellular signals into a variety of intracellular responses ranging from cell proliferation to apoptosis. Nine PKC genes have been identified in the human genome, which encode 10 proteins. Each member of this protein kinase family displays distinct biochemical characteristics and is enriched in different cellular and subcellular locations. Activation of PKC has been implicated in the regulation of cell growth and differentiation. This review summarizes works of the past years in the field of PKC biochemistry that covers regulation and activation mechanism of different PKC isoforms.

Keywords

PKC biochemistry PKC kinase PKC phosphatases PKC structure 

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© Higher Education Press and Springer-Verlag Berlin Heidelberg 2011

Authors and Affiliations

  1. 1.Laboratory of Computational BiochemistryKN Biomedical Research InstituteBarisalBangladesh
  2. 2.Quality Control SectionOpsonin Pharma LtdBarisalBangladesh

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