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Opioid Use, Gut Dysbiosis, Inflammation, and the Nervous System

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Abstract

Opioid use disorder (OUD) is defined as the chronic use or misuse of prescribed or illicitly obtained opioids and is characterized by clinically significant impairment. The etiology of OUD is multifactorial as it is influenced by genetics, environmental factors, stress response and behavior. Given the profound role of the gut microbiome in health and disease states, in recent years there has been a growing interest to explore interactions between the gut microbiome and the central nervous system as a causal link and potential therapeutic source for OUD. This review describes the role of the gut microbiome and opioid-induced immunopathological disturbances at the gut epithelial surface, which collectively contribute to OUD and perpetuate the vicious cycle of addiction and relapse.

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Acknowledgements

This work was supported by the National Institutes of Health Grants (R01DA044582, R01DA043252, R01DA050542, R01DK117576, and T32DA045734) awarded to SR, by the Miami Center for AIDS Research (CFAR) via a pilot grant (P30AI073961) awarded to SM, and by the University of Miami Scientific Awards Committee (UM SAC) pilot grant (PG013459) and the Miami CFAR pilot grant (GR009434) to US.

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  1. Department of Surgery, University of Miami Miller School of Medicine, Miami, FL, 33136, USA

    Richa Jalodia, Yaa Fosuah Abu, Mark Ryan Oppenheimer, Bridget Herlihy, Jingjing Meng, Irina Chupikova, Junyi Tao, Nillu Ghosh, Rajib Kumar Dutta, Udhghatri Kolli, Yan Yan, Eridania Valdes, Madhulika Sharma, Umakant Sharma, Shamsudheen Moidunny & Sabita Roy

  2. Department of Microbiology and Immunology, University of Miami Miller School of Medicine, Miami, FL, 33136, USA

    Yaa Fosuah Abu

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Jalodia, R., Abu, Y.F., Oppenheimer, M.R. et al. Opioid Use, Gut Dysbiosis, Inflammation, and the Nervous System. J Neuroimmune Pharmacol 17, 76–93 (2022). https://doi.org/10.1007/s11481-021-10046-z

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