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The Impact of Alcohol-Induced Dysbiosis on Diseases and Disorders of the Central Nervous System

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Abstract

The human digestive tract contains a diverse and abundant microbiota that is important for health. Excessive alcohol use can disrupt the balance of these microbes (known as dysbiosis), leading to elevated blood endotoxin levels and systemic inflammation. Using QIAGEN Ingenuity Pathway Analysis (IPA) bioinformatics tool, we have confirmed that peripheral endotoxin (lipopolysaccharide) mediates various cytokines to enhance the neuroinflammation signaling pathway. The literature has identified alcohol-mediated neuroinflammation as a possible risk factor for the onset and progression of neurodegenerative diseases, including Alzheimer’s disease (AD) and Parkinson’s disease (PD), and psychiatric disorders such as addiction to alcohol and other drugs. In this review, we discuss alcohol-use-induced dysbiosis in the gut and other body parts as a causal factor in the progression of Central Nervous System (CNS) diseases including neurodegenerative disease and possibly alcohol use disorder.

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Acknowledgements

This study was partially supported by National Institutes of Health grants AA026071, and DA046258 to SLC. Parts of graphical abstract was created with BioRender.com.

Funding

This study was partially supported by National Institutes of Health grants AA026071, and DA046258 to SLC.

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Authors and Affiliations

  1. Institute of Neuroimmune Pharmacology, Seton Hall University, South Orange, NJ, 07079, USA

    Xiangqian Liu, Michael Vigorito, Wenfei Huang & Sulie L. Chang

  2. Department of Histology and Embryology, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, P.R. China

    Xiangqian Liu

  3. Department of Psychology, Seton Hall University, South Orange, NJ, 07079, USA

    Michael Vigorito

  4. Department of Biological Sciences, Seton Hall University, South Orange, NJ, 07079, USA

    Wenfei Huang & Sulie L. Chang

  5. Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Harvard Medical School and Shriners Hospital for Children, Boston, MA, 02114, USA

    Mohammed A. S. Khan

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SLC had the idea for the article, XL, MV, MK, WH, SLC performed the literature search, data analysis, drafted and critically revised the work.

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Liu, X., Vigorito, M., Huang, W. et al. The Impact of Alcohol-Induced Dysbiosis on Diseases and Disorders of the Central Nervous System. J Neuroimmune Pharmacol 17, 131–151 (2022). https://doi.org/10.1007/s11481-021-10033-4

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