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Journal of Neuroimmune Pharmacology

, Volume 11, Issue 3, pp 456–470 | Cite as

Novelty Seeking and Drug Addiction in Humans and Animals: From Behavior to Molecules

  • Taylor Wingo
  • Tanseli Nesil
  • Jung-Seok Choi
  • Ming D. LiEmail author
INVITED REVIEW

Abstract

Global treatment of drug addiction costs society billions of dollars annually, but current psychopharmacological therapies have not been successful at desired rates. The increasing number of individuals suffering from substance abuse has turned attention to what makes some people more vulnerable to drug addiction than others. One personality trait that stands out as a contributing factor is novelty seeking. Novelty seeking, affected by both genetic and environmental factors, is defined as the tendency to desire novel stimuli and environments. It can be measured in humans through questionnaires and in rodents using behavioral tasks. On the behavioral level, both human and rodent studies demonstrate that high novelty seeking can predict the initiation of drug use and a transition to compulsive drug use and create a propensity to relapse. These predictions are valid for several drugs of abuse, such as alcohol, nicotine, cocaine, amphetamine, and opiates. On the molecular level, both novelty seeking and addiction are modulated by the central reward system in the brain. Dopamine is the primary neurotransmitter involved in the overlapping neural substrates of both parameters. In sum, the novelty-seeking trait can be valuable for predicting individual vulnerability to drug addiction and for generating successful treatment for patients with substance abuse disorders.

Keywords

Addiction Drugs of abuse Heritability Molecular connections Novelty seeking 

Notes

Acknowledgments

This work was supported, in part, by US National Institutes of Health grants DA-012844 and DA-026356.

Compliance with Ethical Standards

Conflict of Interest

The authors claim no conflict interest regarding this report.

References

  1. Agrawal A, Lynskey MT (2008) Are there genetic influences on addiction: evidence from family, adoption and twin studies. Addiction 103:1069–1081PubMedCrossRefGoogle Scholar
  2. Agrawal A, Verweij KJ, Gillespie NA, Heath AC, Lessov-Schlaggar CN, Martin NG, Nelson EC, Slutske WS, Whitfield JB, Lynskey MT (2012) The genetics of addiction-a translational perspective. Transl Psychiatry 2:e140PubMedPubMedCentralCrossRefGoogle Scholar
  3. Ahituv N, Kavaslar N, Schackwitz W, Ustaszewska A, Martin J, Hebert S, Doelle H, Ersoy B, Kryukov G, Schmidt S, Yosef N, Ruppin E, Sharan R, Vaisse C, Sunyaev S, Dent R, Cohen J, McPherson R, Pennacchio LA (2007) Medical sequencing at the extremes of human body mass. Am J Hum Genet 80:779–791PubMedPubMedCentralCrossRefGoogle Scholar
  4. Ambrosio E, Goldberg SR, Elmer GI (1995) Behavior genetic investigation of the relationship between spontaneous locomotor activity and the acquisition of morphine self-administration behavior. Behav Pharmacol 6:229–237PubMedCrossRefGoogle Scholar
  5. Andrucci GL, Archer RP, Pancoast DL, Gordon RA (1989) The relationship of mmpi and sensation seeking scales to adolescent drug-use. J Pers Assess 53:253–266PubMedCrossRefGoogle Scholar
  6. Arnett J (1994) Sensation seeking - a new conceptualization and a new scale. Personal Individ Differ 16:289–296CrossRefGoogle Scholar
  7. Ballon N, Brunault P, Cortese S (2015) Sensation seeking and cocaine dependence in adults with reported childhood ADHD. J Atten Disord 19:335–342PubMedCrossRefGoogle Scholar
  8. Bardo MT, Donohew RL, Harrington NG (1996) Psychobiology of novelty seeking and drug seeking behavior. Behav Brain Res 77:23–43PubMedCrossRefGoogle Scholar
  9. Belin D, Deroche-Gamonet V (2012) Responses to novelty and vulnerability to cocaine addiction: contribution of a multi-symptomatic animal model. Cold Spring Harb Perspect Med 2Google Scholar
  10. Bernheim A, Halfon O, Boutrel B (2013) Controversies about the enhanced vulnerability of the adolescent brain to develop addiction. Front Pharmacol 4:118PubMedPubMedCentralCrossRefGoogle Scholar
  11. Bevins RA, Klebaur JE, Bardo MT (1997) Individual differences in response to novelty, amphetamine-induced activity and drug discrimination in rats. Behav Pharmacol 8:113–123PubMedGoogle Scholar
  12. Blanchard MM, Mendelsohn D, Stamp JA (2009) The HR/LR model: further evidence as an animal model of sensation seeking. Neurosci Biobehav Rev 33:1145–1154PubMedCrossRefGoogle Scholar
  13. Blum K, Chen AL, Giordano J, Borsten J, Chen TJ, Hauser M, Simpatico T, Femino J, Braverman ER, Barh D (2012) The addictive brain: all roads lead to dopamine. J Psychoactive Drugs 44:134–143PubMedCrossRefGoogle Scholar
  14. Blum K, Noble EP, Sheridan PJ, Montgomery A, Ritchie T, Jagadeeswaran P, Nogami H, Briggs AH, Cohn JB (1990) Allelic association of human dopamine D2 receptor gene in alcoholism. JAMA 263:2055–2060PubMedCrossRefGoogle Scholar
  15. Boissier JR, Simon P (1962) The exploration reaction in the mouse. Preliminary note. Therapie 17:1225–1232PubMedGoogle Scholar
  16. Bolos AM, Dean M, Lucasderse S, Ramsburg M, Brown GL, Goldman D (1990) Population and pedigree studies reveal a lack of association between the dopamine-D2 receptor gene and alcoholism. Jama-J Am Med Assoc 264:3156–3160CrossRefGoogle Scholar
  17. Bookman EB, Taylor RE, Adams-Campbell L, Kittles RA (2002) DRD4 promoter SNPs and gender effects on extraversion in African Americans. Mol Psychiatry 7:786–789PubMedCrossRefGoogle Scholar
  18. Brown GR, Nemes C (2008) The exploratory behaviour of rats in the hole-board apparatus: is head-dipping a valid measure of neophilia? Behav Process 78:442–448CrossRefGoogle Scholar
  19. Burns L (2014) World drug report 2013 united nations office on drugs and crime. Drug Alcohol Rev 33:216–216CrossRefGoogle Scholar
  20. Cagetti E, Liang J, Spigelman I, Olsen RW (2003) Withdrawal from chronic intermittent ethanol treatment changes subunit composition, reduces synaptic function, and decreases behavioral responses to positive allosteric modulators of GABAA receptors. Mol Pharmacol 63:53–64PubMedCrossRefGoogle Scholar
  21. Cain ME, Saucier DA, Bardo MT (2005) Novelty seeking and drug use: contribution of an animal model. Exp Clin Psychopharmacol 13:367–375PubMedCrossRefGoogle Scholar
  22. Carton S, Le Houezec J, Lagrue G, Jouvent R (2000) Relationships between sensation seeking and emotional symptomatology during smoking cessation with nicotine patch therapy. Addict Behav 25:653–662PubMedCrossRefGoogle Scholar
  23. Chefer VI, Zakharova I, Shippenberg TS (2003) Enhanced responsiveness to novelty and cocaine is associated with decreased basal dopamine uptake and release in the nucleus accumbens: quantitative microdialysis in rats under transient conditions. J Neurosci 23:3076–3084PubMedGoogle Scholar
  24. Chen C, Moyzis R, Dong Q, He Q, Zhu B, Li J, Li H, Lessard J (2011) Sex modulates the associations between the COMT gene and personality traits. Neuropsychopharmacology 36:1593–1598PubMedPubMedCentralCrossRefGoogle Scholar
  25. Cloninger CR (1986) A unified biosocial theory of personality and its role in the development of anxiety states. Psychiatr Dev 4:167–226PubMedGoogle Scholar
  26. Cloninger CR (1987) Neurogenetic adaptive mechanisms in alcoholism. Science 236:410–416PubMedCrossRefGoogle Scholar
  27. Cloninger CR, Przybeck TR, Svrakic DM (1991) The tridimensional personality questionnaire: U.S. normative data. Psychol Rep 69:1047–1057PubMedCrossRefGoogle Scholar
  28. Cloninger CR, Svrakic DM, Przybeck TR (1993) A psychobiological model of temperament and character. Arch Gen Psychiatry 50:975–990PubMedCrossRefGoogle Scholar
  29. Comeau N, Stewart SH, Loba P (2001) The relations of trait anxiety, anxiety sensitivity, and sensation seeking to adolescents' motivations for alcohol, cigarette, and marijuana use. Addict Behav 26:803–825PubMedCrossRefGoogle Scholar
  30. Compton PA, Anglin MD, Khalsa-Denison ME, Paredes A (1996) The D2 dopamine receptor gene, addiction, and personality: clinical correlates in cocaine abusers. Biol Psychiatry 39:302–304PubMedCrossRefGoogle Scholar
  31. Crawford CA, Der-Ghazarian T, Britt CE, Varela FA, Kozanian OO (2013) Novelty-induced conditioned place preference, sucrose preference, and elevated plus maze behavior in adult rats after repeated exposure to methylphenidate during the preweanling period. Behav Brain Res 246:29–35PubMedPubMedCentralCrossRefGoogle Scholar
  32. Crettol S, Besson J, Croquette-Krokar M, Hammig R, Gothuey I, Monnat M, Deglon JJ, Preisig M, Eap CB (2008) Association of dopamine and opioid receptor genetic polymorphisms with response to methadone maintenance treatment. Prog Neuro-Psychopharmacol Biol Psychiatry 32:1722–1727CrossRefGoogle Scholar
  33. Cummings JA, Gowl BA, Westenbroek C, Clinton SM, Akil H, Becker JB (2011) Effects of a selectively bred novelty-seeking phenotype on the motivation to take cocaine in male and female rats. Biol Sex Differ 2:3PubMedPubMedCentralCrossRefGoogle Scholar
  34. Davis BA, Clinton SM, Akil H, Becker JB (2008) The effects of novelty-seeking phenotypes and sex differences on acquisition of cocaine self-administration in selectively bred high-responder and low-responder rats. Pharmacol Biochem Behav 90:331–338PubMedPubMedCentralCrossRefGoogle Scholar
  35. Dervaux A, Laqueille X, Bourdel MC, Olie JP, Krebs MO (2010) Impulsivity and sensation seeking in alcohol abusing patients with schizophrenia. Front Psychiatry 1:135PubMedPubMedCentralCrossRefGoogle Scholar
  36. Ebstein RP (2006) The molecular genetic architecture of human personality: beyond self-report questionnaires. Mol Psychiatry 11:427–445PubMedCrossRefGoogle Scholar
  37. Eichhammer P, Sand PG, Stoertebecker P, Langguth B, Zowe M, Hajak G (2005) Variation at the DRD4 promoter modulates extraversion in caucasians. Mol Psychiatry 10:520–522PubMedCrossRefGoogle Scholar
  38. Ersche KD, Turton AJ, Pradhan S, Bullmore ET, Robbins TW (2010) Drug addiction endophenotypes: impulsive versus sensation-seeking personality traits. Biol Psychiatry 68:770–773PubMedPubMedCentralCrossRefGoogle Scholar
  39. Evenden JL (1999) Varieties sf impulsivity. Psychopharmacology 146:348–361PubMedCrossRefGoogle Scholar
  40. Evren C, Durkaya M, Evren B, Dalbudak E, Cetin R (2012) Relationship of relapse with impulsivity, novelty seeking and craving in male alcohol-dependent inpatients. Drug Alcohol Rev 31:81–90PubMedCrossRefGoogle Scholar
  41. Faingold C, Li Y, Evans MS (2000) Decreased GABA and increased glutamate receptor-mediated activity on inferior colliculus neurons in vitro are associated with susceptibility to ethanol withdrawal seizures. Brain Res 868:287–295PubMedCrossRefGoogle Scholar
  42. Fairbanks LA, Bailey JN, Breidenthal SE, Laudenslager ML, Kaplan JR, Jorgensen MJ (2011) Environmental stress alters genetic regulation of novelty seeking in vervet monkeys. Genes Brain Behav 10:683–688PubMedPubMedCentralCrossRefGoogle Scholar
  43. Finn PR, Mazas CA, Justus AN, Steinmetz J (2002) Early-onset alcoholism with conduct disorder: go/no go learning deficits, working memory capacity, and personality. Alcohol Clin Exp Res 26:186–206PubMedCrossRefGoogle Scholar
  44. Flagel SB, Robinson TE, Clark JJ, Clinton SM, Watson SJ, Seeman P, Phillips PE, Akil H (2010) An animal model of genetic vulnerability to behavioral disinhibition and responsiveness to reward-related cues: implications for addiction. Neuropsychopharmacology 35:388–400PubMedCrossRefGoogle Scholar
  45. Flagel SB, Waselus M, Clinton SM, Watson SJ, Akil H (2014) Antecedents and consequences of drug abuse in rats selectively bred for high and low response to novelty. Neuropharmacology 76 Pt B:425–436.Google Scholar
  46. Fumagalli F, Bedogni F, Maragnoli ME, Gennarelli M, Perez J, Racagni G, Riva MA (2003) Dopaminergic D2 receptor activation modulates FGF-2 gene expression in rat prefrontal cortex and hippocampus. J Neurosci Res 74:74–80PubMedCrossRefGoogle Scholar
  47. Golimbet VE, Gritsenko IK, Alfimova MV, Ebstein RP (2005) Polymorphic markers of the dopamine D4 receptor gene promoter region and personality traits in mentally healthy individuals from the Russian population. Russ J Genet 41:789–793CrossRefGoogle Scholar
  48. Gomez H, Lluch JM, Masgrau L (2012) Essential role of glutamate 317 in galactosyl transfer by alpha3GalT: a computational study. Carbohydr Res 356:204–208PubMedCrossRefGoogle Scholar
  49. Greenwood TA, Badner JA, Byerley W, Keck PE, McElroy SL, Remick RA, Dessa Sadovnick A, Kelsoe JR (2013) Heritability and linkage analysis of personality in bipolar disorder. J Affect Disord 151:748–755PubMedPubMedCentralCrossRefGoogle Scholar
  50. Gulley JM, Hoover BR, Larson GA, Zahniser NR (2003) Individual differences in cocaine-induced locomotor activity in rats: behavioral characteristics, cocaine pharmacokinetics, and the dopamine transporter. Neuropsychopharmacology 28:2089–2101PubMedGoogle Scholar
  51. Han C, McGue MK, Iacono WG (1999) Lifetime tobacco, alcohol and other substance use in adolescent Minnesota twins: univariate and multivariate behavioral genetic analyses. Addiction 94:981–993PubMedCrossRefGoogle Scholar
  52. Hascoet M, Bourin M, Dhonnchadha BAN (2001) The mouse light-dark paradigm: a review. Prog Neuro-Psychopharmacol Biol Psychiatry 25:141–166CrossRefGoogle Scholar
  53. Hawkins JD, Catalano RF, Miller JY (1992) Risk and protective factors for alcohol and other drug problems in adolescence and early adulthood - implications for substance-abuse prevention. Psychol Bull 112:64–105PubMedCrossRefGoogle Scholar
  54. Heck A, Lieb R, Ellgas A, Pfister H, Lucae S, Roeske D, Putz B, Muller-Myhsok B, Uhr M, Holsboer F, Ising M (2009) Investigation of 17 candidate genes for personality traits confirms effects of the HTR2A gene on novelty seeking. Genes Brain Behav 8:464–472PubMedCrossRefGoogle Scholar
  55. Hiroi N, Agatsuma S (2005) Genetic susceptibility to substance dependence. Mol Psychiatry 10:336–344CrossRefPubMedGoogle Scholar
  56. Hooks MS, Jones GH, Smith AD, Neill DB, Justice Jr JB (1991) Response to novelty predicts the locomotor and nucleus accumbens dopamine response to cocaine. Synapse 9:121–128Google Scholar
  57. Hooks MS, Juncos JL, Justice Jr JB, Meiergerd SM, Povlock SL, Schenk JO, Kalivas PW (1994) Individual locomotor response to novelty predicts selective alterations in D1 and D2 receptors and mRNAs. J Neurosci 14:6144–6152Google Scholar
  58. Hosak L (2007) Role of the COMT gene Val158Met polymorphism in mental disorders: a review. Eur Psychiatry 22:276–281PubMedCrossRefGoogle Scholar
  59. Hosak L, Libiger J, Cizek J, Beranek M, Cermakova E (2006) The COMT Val158Met polymorphism is associated with novelty seeking in Czech methamphetamine abusers: preliminary results. Neuro Endocrinol Lett 27:799–802PubMedGoogle Scholar
  60. Howard MO, Kivlahan D, Walker RD (1997) Cloninger's tridimensional theory of personality and psychopathology: applications to substance use disorders. J Stud Alcohol 58:48–66PubMedCrossRefGoogle Scholar
  61. Ismael F, Baltieri DA (2014) Role of personality traits in cocaine craving throughout an outpatient psychosocial treatment program. Rev Bras Psiquiatr 36:24–31PubMedCrossRefGoogle Scholar
  62. Kahler CW, Spillane NS, Metrik J, Leventhal AM, Monti PM (2009) Sensation seeking as a predictor of treatment compliance and smoking cessation treatment outcomes in heavy social drinkers. Pharmacol Biochem Behav 93:285–290PubMedPubMedCentralCrossRefGoogle Scholar
  63. Kalivas PW, Volkow ND (2011) New medications for drug addiction hiding in glutamatergic neuroplasticity. Mol Psychiatry 16:974–986PubMedPubMedCentralCrossRefGoogle Scholar
  64. Kandel DB, Wu P, Davies M (1994) Maternal smoking during pregnancy and smoking by adolescent daughters. Am J Public Health 84:1407–1413PubMedPubMedCentralCrossRefGoogle Scholar
  65. Kang JI, Kim SJ, Song YY, Namkoong K, An SK (2013) Genetic influence of COMT and BDNF gene polymorphisms on resilience in healthy college students. Neuropsychobiology 68:174–180PubMedCrossRefGoogle Scholar
  66. Kelly TH, Robbins G, Martin CA, Fillmore MT, Lane SD, Harrington NG, Rush CR (2006) Individual differences in drug abuse vulnerability: d-amphetamine and sensation-seeking status. Psychopharmacology 189:17–25PubMedPubMedCentralCrossRefGoogle Scholar
  67. Kempton MJ, Haldane M, Jogia J, Christodoulou T, Powell J, Collier D, Williams SC, Frangou S (2009) The effects of gender and COMT Val158Met polymorphism on fearful facial affect recognition: a fMRI study. Int J Neuropsychopharmacol 12:371–381PubMedCrossRefGoogle Scholar
  68. Kendler KS, Jacobson KC, Prescott CA, Neale MC (2003) Specificity of genetic and environmental risk factors for use and abuse/dependence of cannabis, cocaine, hallucinogens, sedatives, stimulants, and opiates in male twins. Am J Psychiatry 160:687–695PubMedCrossRefGoogle Scholar
  69. Khan AA, Jacobson KC, Gardner CO, Prescott CA, Kendler KS (2005) Personality and comorbidity of common psychiatric disorders. Br J Psychiatry 186:190–196PubMedCrossRefGoogle Scholar
  70. Kirby LG, Zeeb FD, Winstanley CA (2011) Contributions of serotonin in addiction vulnerability. Neuropharmacology 61:421–432PubMedPubMedCentralCrossRefGoogle Scholar
  71. Koob GF (2000) Neurobiology of addiction. Toward the Development of new Therapies. Annals of the New York Academy of Sciences 909:170–185PubMedCrossRefGoogle Scholar
  72. Koob GF (2006) The neurobiology of addiction: a neuroadaptational view relevant for diagnosis. Addiction 101(Suppl 1):23–30PubMedCrossRefGoogle Scholar
  73. Krebs RM, Heipertz D, Schuetze H, Duzel E (2011) Novelty increases the mesolimbic functional connectivity of the substantia nigra/ventral tegmental area (SN/VTA) during reward anticipation: evidence from high-resolution fMRI. NeuroImage 58:647–655PubMedCrossRefGoogle Scholar
  74. Lawford BR, Young RM, Noble EP, Sargent J, Rowell J, Shadforth S, Zhang XX, Ritchie T (2000) The D-2 dopamine receptor al allele and opioid dependence: association with heroin use and response to methadone treatment. Am J Med Genet 96:592–598PubMedCrossRefGoogle Scholar
  75. Leccese AP, Lyness WH (1984) The effects of putative 5-hydroxytryptamine receptor active agents on D-amphetamine self-administration in controls and rats with 5,7-dihydroxytryptamine median forebrain-bundle lesions. Brain Res 303:153–162PubMedCrossRefGoogle Scholar
  76. Leyton M, Boileau I, Benkelfat C, Diksic M, Baker G, Dagher A (2002a) Amphetamine-induced increases in extracellular dopamine, drug wanting, and novelty seeking: a PET/[11C]raclopride study in healthy men. Neuropsychopharmacology 27:1027–1035PubMedCrossRefGoogle Scholar
  77. Leyton M, Boileau I, Benkelfat C, Diksic M, Baker G, Dagher A (2002b) Amphetamine-induced increases in extracellular dopamine, drug wanting, and novelty seeking: a PET/[C-11]raclopride study in healthy men. Neuropsychopharmacology 27:1027–1035PubMedCrossRefGoogle Scholar
  78. Li MD, Cheng R, Ma JZ, Swan GE (2003) A meta-analysis of estimated genetic and environmental effects on smoking behavior in male and female adult twins. Addiction 98:23–31PubMedCrossRefGoogle Scholar
  79. Lim SS et al (2012) A comparative risk assessment of burden of disease and injury attributable to 67 risk factors and risk factor clusters in 21 regions, 1990–2010: a systematic analysis for the global burden of disease study 2010. Lancet 380:2224–2260PubMedPubMedCentralCrossRefGoogle Scholar
  80. Long JC, Knowler WC, Hanson RL, Robin RW, Urbanek M, Moore E, Bennett PH, Goldman D (1998) Evidence for genetic linkage to alcohol dependence on chromosomes 4 and 11 from an autosome-wide scan in an American Indian population. Am J Med Genet 81:216–221PubMedCrossRefGoogle Scholar
  81. Lu RB, Ko HC, Chang FM, Castiglione CM, Schoolfield G, Pakstis AJ, Kidd JR, Kidd KK (1996) No association between alcoholism and multiple polymorphisms at the dopamine D2 receptor gene (DRD2) in three distinct taiwanese populations. Biol Psychiatry 39:419–429PubMedCrossRefGoogle Scholar
  82. Mahler SV, Vazey EM, Beckley JT, Keistler CR, McGlinchey EM, Kaufling J, Wilson SP, Deisseroth K, Woodward JJ, Aston-Jones G (2014) Designer receptors show role for ventral pallidum input to ventral tegmental area in cocaine seeking. Nat Neurosci 17:577–U136PubMedPubMedCentralCrossRefGoogle Scholar
  83. Mahoney JJ, Thompson-Lake DGY, Cooper K, Verrico CD, Newton TF, De La Garza R (2015) A comparison of impulsivity, depressive symptoms, lifetime stress and sensation seeking in healthy controls versus participants with cocaine or methamphetamine use disorders. J Psychopharmacol 29:50–56PubMedCrossRefGoogle Scholar
  84. Manzo L, Gomez MJ, Callejas-Aguilera JE, Donaire R, Sabariego M, Fernandez-Teruel A, Canete A, Blazquez G, Papini MR, Torres C (2014) Relationship between ethanol preference and sensation/novelty seeking. Physiol Behav 133:53–60PubMedCrossRefGoogle Scholar
  85. Marinelli M, White FJ (2000) Enhanced vulnerability to cocaine self-administration is associated with elevated impulse activity of midbrain dopamine neurons. J Neurosci 20:8876–8885PubMedGoogle Scholar
  86. Matthes HW, Maldonado R, Simonin F, Valverde O, Slowe S, Kitchen I, Befort K, Dierich A, Le Meur M, Dolle P, Tzavara E, Hanoune J, Roques BP, Kieffer BL (1996) Loss of morphine-induced analgesia, reward effect and withdrawal symptoms in mice lacking the mu-opioid-receptor gene. Nature 383:819–823PubMedCrossRefGoogle Scholar
  87. Meszaros K, Lenzinger E, Hornik K, Fureder T, Willinger U, Fischer G, Schonbeck G, Aschauer HN (1999) The tridimensional personality questionnaire as a predictor of relapse in detoxified alcohol dependents. The european fluvoxamine in alcoholism study group. Alcohol Clin Exp Res 23:483–486PubMedCrossRefGoogle Scholar
  88. Meyer AC, Rahman S, Charnigo RJ, Dwoskin LP, Crabbe JC, Bardo MT (2010) Genetics of novelty seeking, amphetamine self-administration and reinstatement using inbred rats. Genes Brain Behav 9:790–798PubMedPubMedCentralCrossRefGoogle Scholar
  89. Montag C, Jurkiewicz M, Reuter M (2012) The role of the catechol-O-methyltransferase (COMT) gene in personality and related psychopathological disorders. CNS Neurol Disord Drug Targets 11:236–250PubMedPubMedCentralCrossRefGoogle Scholar
  90. Nadal R, Armario A, Janak PH (2002) Positive relationship between activity in a novel environment and operant ethanol self-administration in rats. Psychopharmacology 162:333–338PubMedCrossRefGoogle Scholar
  91. Nakamura Y, Ito Y, Aleksic B, Kushima I, Yasui-Furukori N, Inada T, Ono Y, Ozaki N (2010) Influence of HTR2A polymorphisms and parental rearing on personality traits in healthy Japanese subjects. J Hum Genet 55:838–841PubMedCrossRefGoogle Scholar
  92. Nesil T, Kanit L, Li MD, Pogun S (2013) Nine generations of selection for high and low nicotine intake in outbred Sprague-Dawley rats. Behav Genet 43:436–444PubMedCrossRefGoogle Scholar
  93. Netter P, Hennig J, Roed IS (1996) Serotonin and dopamine as mediators of sensation seeking behavior. Neuropsychobiology 34:155–165PubMedCrossRefGoogle Scholar
  94. Okuyama Y, Ishiguro H, Nankai M, Shibuya H, Watanabe A, Arinami T (2000) Identification of a polymorphism in the promoter region of DRD4 associated with the human novelty seeking personality trait. Mol Psychiatry 5:64–69PubMedCrossRefGoogle Scholar
  95. Pelloux Y, Costentin J, Duterte-Boucher D (2015) Differential involvement of anxiety and novelty preference levels on oral ethanol consumption in rats. Psychopharmacology (Berl).Google Scholar
  96. Piazza PV, Deminiere JM, Le Moal M, Simon H (1989) Factors that predict individual vulnerability to amphetamine self-administration. Science 245:1511–1513PubMedCrossRefGoogle Scholar
  97. Piazza PV, Deroche-Gamonent V, Rouge-Pont F, Le Moal M (2000) Vertical shifts in self-administration dose-response functions predict a drug-vulnerable phenotype predisposed to addiction. J Neurosci 20:4226–4232PubMedGoogle Scholar
  98. Ronai Z, Szekely A, Nemoda Z, Lakatos K, Gervai J, Staub M, Sasvari-Szekely M (2001) Association between novelty seeking and the-521 C/T polymorphism in the promoter region of the DRD4 gene. Mol Psychiatry 6:35–38PubMedCrossRefGoogle Scholar
  99. Rossetti ZL, Carboni S (1995) Ethanol withdrawal is associated with increased extracellular glutamate in the rat striatum. Eur J Pharmacol 283:177–183PubMedCrossRefGoogle Scholar
  100. Sabeti J, Gerhardt GA, Zahniser NR (2002) Acute cocaine differentially alters accumbens and striatal dopamine clearance in low and high cocaine locomotor responders: behavioral and electrochemical recordings in freely moving rats. J Pharmacol Exp Ther 302:1201–1211PubMedCrossRefGoogle Scholar
  101. Schepis TS, Desai RA, Smith AE, Cavallo DA, Liss TB, McFetridge A, Potenza MN, Krishnan-Sarin S (2008) Impulsive sensation seeking, parental history of alcohol problems, and current alcohol and tobacco use in adolescents. J Addict Med 2:185–193PubMedPubMedCentralCrossRefGoogle Scholar
  102. Schneider Jr R, Ottoni GL, de Carvalho HW, Elisabetsky E, Lara DR (2015) Temperament and character traits associated with the use of alcohol, cannabis, cocaine, benzodiazepines, and hallucinogens: evidence from a large Brazilian web survey. Rev Bras Psiquiatr 37:31–39Google Scholar
  103. See RE, Fuchs RA, Ledford CC, McLaughlin J (2003) Drug addiction, relapse, and the amygdala. Ann N Y Acad Sci 985:294–307PubMedCrossRefGoogle Scholar
  104. Spear LP (2000) The adolescent brain and age-related behavioral manifestations. Neurosci Biobehav Rev 24:417–463PubMedCrossRefGoogle Scholar
  105. Stautz K, Cooper A (2013) Impulsivity-related personality traits and adolescent alcohol use: a meta-analytic review. Clin Psychol Rev 33:574–592PubMedCrossRefGoogle Scholar
  106. Stead JD, Clinton S, Neal C, Schneider J, Jama A, Miller S, Vazquez DM, Watson SJ, Akil H (2006) Selective breeding for divergence in novelty-seeking traits: heritability and enrichment in spontaneous anxiety-related behaviors. Behav Genet 36:697–712PubMedCrossRefGoogle Scholar
  107. Sutker PB, Archer RP, Allain AN (1978) Drug abuse patterns, personality characteristics, and relationships with sex, race, and sensation seeking. J Consult Clin Psychol 46:1374–1378PubMedCrossRefGoogle Scholar
  108. Suto N, Austin JD, Vezina P (2001) Locomotor response to novelty predicts a rat's propensity to self-administer nicotine. Psychopharmacology 158:175–180PubMedCrossRefGoogle Scholar
  109. Thanos PK, Roushdy K, Sarwar Z, Rice O, Ashby Jr CR, Grandy DK (2015) The effect of dopamine D4 receptor density on novelty seeking, activity, social interaction, and alcohol binge drinking in adult mice. Synapse 69:356–364Google Scholar
  110. Toda S (2012) [The role of the striatum in addiction]. brain and nerve =. Shinkei Kenkyu no Shinpo 64:911–917PubMedGoogle Scholar
  111. Tournier BB, Steimer T, Millet P, Moulin-Sallanon M, Vallet P, Ibanez V, Ginovart N (2013) Innately low D2 receptor availability is associated with high novelty-seeking and enhanced behavioural sensitization to amphetamine. Int J Neuropsychopharmacol 16:1819–1834PubMedCrossRefGoogle Scholar
  112. Vanhille N, Belin-Rauscent A, Mar AC, Ducret E, Belin D (2015) High locomotor reactivity to novelty is associated with an increased propensity to choose saccharin over cocaine: new insights into the vulnerability to addiction. Neuropsychopharmacology 40:577–589PubMedCrossRefGoogle Scholar
  113. Walters GD (2002) The heritability of alcohol abuse and dependence: a meta-analysis of behavior genetic research. Am J Drug Alcohol Abuse 28:557–584PubMedCrossRefGoogle Scholar
  114. Wang Y, Liu Y, Yang LZ, Gu F, Li XM, Zha RJ, Wei ZD, Pei YK, Zhang P, Zhou YF, Zhang XC (2015) Novelty seeking is related to individual risk preference and brain activation associated with risk prediction during decision making. Sci Rep-UK 5Google Scholar
  115. Welker WI (1957) Free and forced exploration of a novel situation by rats. Psychol. Rep 3:95–108Google Scholar
  116. Weyandt LL (2005) The Physiological Bases of Cognitive and Behavioral Disorders: Routledge.Google Scholar
  117. Zheng X, Ke X, Tan B, Luo X, Xu W, Yang X, Sui N (2003) Susceptibility to morphine place conditioning: relationship with stress-induced locomotion and novelty-seeking behavior in juvenile and adult rats. Pharmacol Biochem Behav 75:929–935PubMedCrossRefGoogle Scholar
  118. Zhu J, Apparsundaram S, Bardo MT, Dwoskin LP (2005) Environmental enrichment decreases cell surface expression of the dopamine transporter in rat medial prefrontal cortex. J Neurochem 93:1434–1443PubMedCrossRefGoogle Scholar
  119. Zuckerman M (2007) The sensation seeking scale V (SSS-V): still reliable and valid. Personal Individ Differ 43:1303–1305CrossRefGoogle Scholar
  120. Zuckerman M, Cloninger CR (1996) Relationships between Cloninger's, Zuckerman's, and Eysenck's dimensions of personality. Personality and Individual Differences 21:283–285Google Scholar
  121. Zuckerman M, Neeb M (1979) Sensation seeking and psychopathology. Psychiatry Res 1:255–264PubMedCrossRefGoogle Scholar
  122. Zuckerman M, Kuhlman DM, Joireman J, Teta P, Kraft M (1993) A comparison of 3 structural models for personality - the big 3, the big 5, and the alternative 5. J Pers Soc Psychol 65:757–768CrossRefGoogle Scholar

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© Springer Science+Business Media New York 2015

Authors and Affiliations

  • Taylor Wingo
    • 1
  • Tanseli Nesil
    • 1
  • Jung-Seok Choi
    • 1
    • 2
  • Ming D. Li
    • 1
    Email author
  1. 1.Department of Psychiatry and Neurobehavioral SciencesUniversity of VirginiaCharlottesvilleUSA
  2. 2.Department of Psychiatry, SMG-SNU Boramae Medical Center and Department of Psychiatry and Behavioral ScienceSeoul National University College of MedicineSeoulRepublic of Korea

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