Journal of Neuroimmune Pharmacology

, Volume 8, Issue 4, pp 760–762

A Tribute to Jenny S. Henkel, Ph.D. (1955–2013)

COMMENTARY

Keywords

ALS Microglia Regulatory T-lymphocytes FoxP3 

References

  1. Henkel JS, Engelhardt JI, Siklos L, Simpson EP, Kim SH, Pan T, Goodman JC, Siddique T, Beers DR, Appel SH (2004) Presence of dendritic cells, MCP-1, and activated microglia/macrophages in amyotrophic lateral sclerosis spinal cord tissue. Ann Neurol 55(2):221–235PubMedCrossRefGoogle Scholar
  2. Henkel JS, Beers DR, Siklós L, Appel SH (2006) The chemokine MCP-1 and the dendritic and myeloid cells it attracts are increased in the mSOD1 mouse model of ALS. Mol Cell Neurosci 31(3):427–437PubMedCrossRefGoogle Scholar
  3. Beers DR*, Henkel JS*, Xiao Q, Zhao W, Wang J, Yen AA, Siklos L, McKercher SR, Appel SH (2006) Wild-type microglia extend survival in PU.1 knockout mice with familial amyotrophic lateral sclerosis. PNAS 103(43):16021–16026. These authors contributed equally to the work Google Scholar
  4. Beers DR*, Henkel JS*, Zhao W, Wang J, Appel SH (2008) CD4+ T-cells support glial neuroprotection, slow disease progression, and modify glial morphology in an animal model of inherited ALS. PNAS 105(40):15558–15563. These authors contributed equally to the work Google Scholar
  5. Beers DR*, Henkel JS*, Zhao W, Wang J, Huang A, Wen S, Liao B, Appel SH (2011) Endogenous tregs ameliorate disease in ALS mice and correlate with disease progression in ALS patients. Brain 134(Pt 5):1293–1314. These authors contributed equally to the work Google Scholar
  6. Henkel JS, Beers DR, Wen S, Rivera AL, Toennis KM, Appel JE, Zhao W, Moore DH, Powell SZ, Appel SH (2013) Regulatory T-lymphocytes mediate amyotrophic lateral sclerosis progression and survival. EMBO Mol Med 5:64–79PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  1. 1.Department of NeurologyMethodist Neurological InstituteHoustonUSA

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