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Wnt/beta-Catenin Signaling in Glioma

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Journal of Neuroimmune Pharmacology Aims and scope Submit manuscript

Abstract

Extensive data have shown that Wnt/beta-catenin signaling is associated with various disease pathologies, including an important role in tumorigenesis. Here, we review the regulation of Wnt/beta-catenin signaling in glioma, with particular focus on the expression signatures of the main components in Wnt/beta-catenin signaling, the role of key factors in Wnt/beta-catenin signaling, and crosstalk with other signaling pathways. Finally, we discuss the involvement of microRNAs in Wnt/beta-catenin signaling in glioma. This review reveals new insights into the role of Wnt/beta-catenin signaling in gliomagenesis, and highlights new therapeutic approaches for glioma, based on the modulation of the Wnt/beta-catenin pathway.

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Abbreviations

TCF/LEF:

T cell factor/lymphoid enhancer factor

LRP:

LDL-receptor-related protein

Dsh:

Disheveled

APC:

Adenomatous polyposis coli

GSK:

Glycogen synthase kinase

CtBP:

C-terminal-binding protein

CK1:

Casein kinase 1

CBP:

Cyclic AMP response element-binding protein

p300:

E1A binding protein p300

DKK:

Dickkopf

SFRP:

Secreted frizzled-related proteins

UCSC:

University of California Santa Cruz

WIF:

Wnt inhibitory factor

HSPG:

Heparin-sulfated forms of proteoglycans

EGFR:

Epidermal growth factor receptor

PKM2:

Pyruvate kinase M2

STAT3:

Signal transducer and activator of transcription 3

UTR:

Untranslated region

PI3K:

Phosphatidylinositol 3-kinase

VHL:

Von Hippel-Lindau

NSAIDs:

Nonsteroidal anti-inflammatory drugs

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Acknowledgments

This work was supported by the China National Natural Scientific Fund (30971136, 30872657), the Tianjin Science and Technology Committee (09JCZDJC17600), the Program for New Century Excellent Talents in University (NCET-07-0615) and the National High Technology Research and Development Program 863 (2012AA02A508).

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Authors and Affiliations

  1. Department of Neurosurgery, Tianjin Medical University General Hospital, Tianjin, 300052, People’s Republic of China

    Kailiang Zhang, Junxia Zhang, Lei Han, Peiyu Pu & Chunsheng Kang

  2. Laboratory of Neuro-Oncology, Tianjin Neurological Institute, 154, Anshan Road, Heping, Tianjin, 300052, People’s Republic of China

    Kailiang Zhang, Junxia Zhang, Lei Han, Peiyu Pu & Chunsheng Kang

  3. Key Laboratory of Post-trauma Neuro-repair and Regeneration in Central Nervous System, Ministry of Education, Tianjin, 300052, People’s Republic of China

    Kailiang Zhang, Junxia Zhang, Lei Han, Peiyu Pu & Chunsheng Kang

  4. Tianjin Key Laboratory of Injuries, Variations and Regeneration of Nervous System, Tianjin, 300052, People’s Republic of China

    Kailiang Zhang, Junxia Zhang, Lei Han, Peiyu Pu & Chunsheng Kang

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  1. Kailiang Zhang
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  2. Junxia Zhang
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  3. Lei Han
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  4. Peiyu Pu
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Correspondence to Chunsheng Kang.

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Kailiang Zhang and Junxia Zhang contributed equally to this work.

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Zhang, K., Zhang, J., Han, L. et al. Wnt/beta-Catenin Signaling in Glioma. J Neuroimmune Pharmacol 7, 740–749 (2012). https://doi.org/10.1007/s11481-012-9359-y

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