Journal of Neuroimmune Pharmacology

, Volume 5, Issue 3, pp 267–270 | Cite as

Viral Infections of the Central Nervous System: Pathogenesis to Therapeutics

  • Samantha S. SoldanEmail author
  • Steven Jacobson

Viral infections of the CNS have been implicated in many debilitating illnesses including chronic neurodegenerative and neuroinflammatory disorders, neuropsychiatric conditions, acute encephalitis, and CNS malignancies. Although the effects of these manifold diseases are devastating, leading to death in some instances, the armamentarium of effective vaccines and therapeutics at our disposal to prevent and treat virus-mediated disorders of the CNS is astoundingly limited. It is, therefore, critical that we achieve a better understanding of the common mechanisms of neuroinflammation and neurodegeneration involved in these disorders so that more effective therapeutics can be developed. In this special issue of the Journal of Neuroimmune Pharmacology, we have assembled an extraordinary collection of contributions, including both comprehensive reviews and primary research articles, from leaders in the field of neurovirology. The manuscripts contained herein focus on a variety of CNS...


neurovirology HIV-1 antivirals HAART HTLV-I HERVs PML alphaherpesvirus TMEV measles arbovirus encephalitides MHV multiple sclerosis coronavirus neuroinflammation immunomodulatory 



We thank Howard E. Gendelman, Editor-in-Chief, and Robin Taylor, Managing Editor, for their assistance in preparing this special issue. SSS is supported by PHS grant 1R01AI074626-01. The authors declare that they have no conflicts of interest.


  1. Ascherio A, Munger KL (2010) Epstein–Barr virus infection and multiple sclerosis: a review. J Neuroimmune Pharmacol. doi: 10.1007/s11481-010-9201-3
  2. Bender SJ, Weiss SR (2010) Pathogenesis of murine Coronavirus in the central nervous system. J Neuroimmune Pharmacol. doi: 10.1007/s11481-010-9202-2
  3. Christensen T (2010) HERVs in Neuropathogenesis. J Neuroimmune Pharmacol. doi: 10.1007/s11481-010-9214-y
  4. Gorantla S, Makarov E, Roy D, Finke-Dwyer J, Murrin LC, Gendelman HE, Poluektova L (2010) Immunoregulation of a CB2 receptor agonist in a murine model of neuroAIDS. J Neuroimmune Pharmacol. doi: 10.1007/s11481-010-9225-8
  5. Hollidge BS, Gonzalez-Scarano F, Soldan SS (2010) Arboviral encephalitides: transmission, emergence, and pathogenesis. J Neuroimmune Pharmacol, 5. doi: 10.1007/s11481-010-9234-7
  6. Kang SS, McGavern DB (2010) Microbial induction of vascular pathology in the CNS. J Neuroimmune Pharmacol. doi: 10.1007/s11481-010-9208-9
  7. Lindl KA, Marks DR, Kolson DL, Jordan-Sciutto KL (2010) HIV-associated neurocognitive disorder: pathogenesis and therapeutic opportunities. J Neuroimmune Pharmacol. doi: 10.1007/s11481-010-9205-z
  8. Marshall LJ, Major EO (2010) Molecular regulation of JC virus tropism: insights into potential therapeutic targets for progressive multifocal leukoencephalopathy. J Neuroimmune Pharmacol. doi: 10.1007/s11481-010-9203-1
  9. Matsuura E, Yamano Y, Jacobson S (2010) Neuroimmunity of HTLV-I infection. J Neuroimmune Pharmacol. doi: 10.1007/s11481-010-9216-9
  10. O'Donnell LA, Rall GF (2010) Blue moon Neurovirology: the merits of studying rare CNS diseases of viral origin. J Neuroimmune Pharmacol. doi: 10.1007/s11481-010-9200-4
  11. Saddawi-Konefka R, Crawford JR (2010) Chronic viral infection and primary central nervous system malignancy. J Neuroimmune Pharmacol. doi: 10.1007/s11481-010-9204-0
  12. Shah S, Nonnemacher MR, Pirrone V, Wigdahl B (2010) Innate and adaptive factors regulating human immunodeficiency virus type 1 genomic activation. J Neuroimmune Pharmacol. doi: 10.1007/s11481-010-9207-x
  13. Szpara ML, Kobiler O, Enquist LW (2010) A common neuronal response to alphaherpesvirus infection. J Neuroimmune Pharmacol. doi: 10.1007/s11481-010-9212-0
  14. Tsunoda I, Fujinami RS (2009) Neuropathogenesis of Theiler's murine encephalomyelitis virus infection, an animal model for multiple sclerosis. J Neuroimmune Pharmacol. doi: 10.1007/s11481-009-9179-x
  15. Yao K, Graham J, Akahata Y, Oh U, Jacobson S (2010) Mechanism of neuroinflammation: enhanced cytotoxicity and IL-17 production via CD46 binding. J Neuroimmune Pharmacol 5. doi: 10.1007/s11481-010-9232-9

Copyright information

© Springer Science+Business Media, LLC 2010

Authors and Affiliations

  1. 1.Department of NeurologyUniversity of PennsylvaniaPhiladelphiaUSA
  2. 2.Viral Immunology Section, Neuroimmunology BranchNIHBethesdaUSA

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