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The Domain and Conformational Organization in Potassium Voltage-Gated Ion Channels

Journal of Neuroimmune Pharmacology volume 4, Article number: 71 (2009) Cite this article

Abstract

Potassium ion channels play critical roles in cell function, providing the maintenance of the membrane, repolarization of action potentials, and the regulation of firing frequency. Mutations in genes that interfere with Kv ion channel function cause severe inherited diseases, such as episodic ataxia type 1, deafness, epilepsy, or cardiac arrhythmia. Because of their critical role in the central nervous system, all ion channels are targets for multiple pharmacologically active compounds. Better understanding of the structure and function of Kv channels may eventually contribute to a more effective design of drugs. In this review, we show the recent data about domain organization of eukaryotic potassium voltage-gated ion channels. We are giving special attention to the interaction between the domains and the corresponding conformational changes upon activation of the channel.

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Acknowledgments

Authors thank Dennis Wray and Elizabeth Stroupe for critical reading and comments on the manuscript. We are thankful to Carole Williams and Kene Piasta for proofreading the manuscript. This work was supported in part by grants from the EU FP7 program, EDICT (No 201924) and RFBR (no. 08-04-01348-а) to OS.

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Affiliations

  1. Department of Bioengineering, Moscow State University, Faculty of Biology, 1, Leninskie Gory, Bld 12, 119991, Moscow, Russia

    Anastasia V. Pischalnikova & Olga S. Sokolova

  2. Institute of Biochemistry RAS, 33 Leninsky ave, Bld 2, 119071, Moscow, Russia

    Olga S. Sokolova

Authors
  1. Anastasia V. Pischalnikova
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  2. Olga S. Sokolova
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Correspondence to Olga S. Sokolova.

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Pischalnikova, A.V., Sokolova, O.S. The Domain and Conformational Organization in Potassium Voltage-Gated Ion Channels. J Neuroimmune Pharmacol 4, 71 (2009). https://doi.org/10.1007/s11481-008-9130-6

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  • DOI: https://doi.org/10.1007/s11481-008-9130-6

Keywords

  • Kv potassium channel
  • domain organization
  • conformational changes
  • 3D structure