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Clinical-Dynamic Features of Affective Disorders Comorbid with Alcohol Dependence

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Abstract

Comorbidity of affective disorders (AD) and alcohol dependence (AlD) worsens prognosis and efficiency of therapy, exacerbates non-compliance in patients, and lowers their level of social adjustment. To study the influence of AlD on clinical-dynamic characteristics of AD, two groups of patients were examined and compared. The study group included 32 patients with AD and comorbid AlD. The comparison group included 31 AD patients without comorbid addictive pathology. The patients of compared groups did not have statistical differences (p > 0.05) according to sex, age, and AD. The Clinical Global Impression scale (CGI), Hamilton Depression Rating Scale (HDRS-17), Hamilton Anxiety Rating Scale (HARS), and Social Adaptation Self-evaluation Scale (SASS) were used. Compared to the group without comorbidity, the group of patients with comorbid AD and AlD had more frequent suicide attempts in their medical history, a high level of anxiety according to HARS, severe disorders according to CGI-S, and difficult and impaired social adaptation according to SASS; patients with recurrent depressive disorder (RDD) and bipolar disorder (BD) also experienced a larger number of affective episodes per year. AlD comorbid with AD affects clinical-dynamic indicators and levels of social adjustment in patients.

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References

  • Bokhan, N. A., Mandel, A. I., Kuznetsov, V. N., Rakhmazova, L. D., Axenov, M. M., Perchatkina, O. E., & Repetsky, D. N. (2017). Alkogolizm i faktory suitsidal'nosti sredi korennogo naseleniya rayonov, priravnennykh k Kraynemu Severu [alcoholism and suicidality factors among indigenous population of territories given the same status as far north]. Suicidology, 8(1), 68–76 (in Russ.).

    Google Scholar 

  • Boschloo, L., Vogelzangs, N., Smit, J. H., van den Brink, W., Veltman, D. J., Beekman, A. T., & Penninx, B. W. (2011). Comorbidity and risk indicators for alcohol use disorders among persons with anxiety and/or depressive disorders: Findings from the Netherlands study of depression and anxiety (NESDA). Journal of Affective Disorders, 131(1–3), 233–242. https://doi.org/10.1016/j.jad.2010.12.014.

    Article  PubMed  Google Scholar 

  • Bulloch, A., Lavorato, D., Williams, J., & Patten, S. (2012). Alcohol consumption and major depression in the general population: critical importance of dependence. Depression and Anxiety, 29(12), 1058–1064. https://doi.org/10.1002/da.22001.

    Article  PubMed  Google Scholar 

  • Cardoso, B. M., Kauer Sant’Anna, M., Dias, V. V., Andreazza, A. C., Ceresér, K. M., & Kapczinski, F. (2008). The impact of co-morbid alcohol use disorder in bipolar patients. Alcohol, 42(6), 451–457. https://doi.org/10.1016/j.alcohol.2008.05.003.

    Article  PubMed  Google Scholar 

  • Cristal, G. (2000). Narushenie emotsional'nogo razvitiya pri addiktivnom povedenii [impairment of emotional development in addictive behavior]. In S. Dauling (Ed.), Psikhologiya i lechenie zavisimogo povedeniya [Psychology and treatment of dependent behavior] (pp. 11–27). Moscow: Klass (in Russ.).

    Google Scholar 

  • Crum, R. M., La Flair, L., Storr, C. L., Green, K. M., Stuart, E. A., Alvanzo, A. A., et al. (2013a). Reports of drinking to self-medicate anxiety symptoms: Longitudinal assessment for subgroups of individuals with alcohol dependence. Depression and Anxiety, 30(2), 174–183. https://doi.org/10.1002/da.22024.

    Article  PubMed  Google Scholar 

  • Crum, R. M., Mojtabai, R., Lazareck, R., Bolton, J. M., Robinson, J., Sareen, J., et al. (2013b). Drinking to self-medicate mood symptoms: association with development of alcohol dependence. JAMA Psychiatry, 70(7), 718–726. https://doi.org/10.1001/jamapsychiatry.2013.1098.

    Article  PubMed  PubMed Central  Google Scholar 

  • Falk, D. E., Yi, H. Y., & Hilton, M. E. (2008). Age of onset and temporal sequencing of lifetime DSM-IV alcohol use disorders relative to comorbid mood and anxiety disorders. Drug and Alcohol Dependence, 94(1–3), 234–245. https://doi.org/10.1016/j.drugalcdep.2007.11.022.

    Article  PubMed  PubMed Central  Google Scholar 

  • Hashimoto, E., Tayama, M., Ishikawa, H., Yamamoto, M., & Saito, T. (2015). Influence of comorbid alcohol use disorder on treatment response of depressive patients. Journal of Neural Transmission, 122(2), 301–306. https://doi.org/10.1007/s00702-014-1254-7.

    Article  CAS  PubMed  Google Scholar 

  • Iovieno, N., Tedeschini, E., Bentley, K. H., Evins, A. E., & Papakostas, G. I. (2011). Antidepressants for major depressive disorder and dysthymic disorder in patients with comorbid alcohol use disorders: meta-analysis of placebo-controlled randomized trials. Journal of Clinical Psychiatry, 72(8), 1144–1151. https://doi.org/10.4088/JCP.10m06217.

    Article  Google Scholar 

  • Joslyn, C., Hawes, D. J., Hunt, C., & Mitchell, P. B. (2016). Is age of onset associated with severity, prognosis, and clinical features in bipolar disorder? A meta-analytic review. Bipolar Disorders, 18(5), 389–403. https://doi.org/10.1111/bdi.12419.

    Article  PubMed  Google Scholar 

  • Katz, R. S., & Kravitz, H. M. (1996). Fibromyalgia, depression and alcoholism: A family history study. The Journal of Rheumatology, 23(1), 149–154.

    CAS  PubMed  Google Scholar 

  • Kessler, R. C., Petukhova, M., & Zaslavsky, A. M. (2011). The role of latent internalizing and externalizing predispositions in accounting for the development of comorbidity among common mental disorders. Current Opinion in Psychiatry, 24(4), 307–312. https://doi.org/10.1097/YCO.0b013e3283477b22.

    Article  PubMed  PubMed Central  Google Scholar 

  • Kessler, R. C., Sampson, N. A., Berglund, P., Gruber, M. J., Al-Hamzawi, A., Andrade, L., et al. (2015). Anxious and non-anxious major depressive disorder in the World Health Organization world mental health surveys. Epidemiology and Psychiatric Sciences, 24(3), 210–226. https://doi.org/10.1017/S2045796015000189.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Merikangas, K. R., & Pato, M. (2009). Recent developments in the epidemiology of bipolar disorder in adults and children: Magnitude, correlates, and future direction. Clinical Psychology: Science and Practice, 16(2), 121–133.

    Google Scholar 

  • Merikangas, K. R., Jin, R., He, J. P., Kessler, R. C., Lee, S., Sampson, N. A., Viana, M. C., Andrade, L. H., Hu, C., Karam, E. G., Ladea, M., Medina-Mora, M. E., Ono, Y., Posada-Villa, J., Sagar, R., Wells, J. E., & Zarkov, Z. (2011). Prevalence and correlates of bipolar spectrum disorder in the world mental health survey initiative. Archives of General Psychiatry, 68(3), 241–251. https://doi.org/10.1001/archgenpsychiatry.2011.12.

    Article  PubMed  PubMed Central  Google Scholar 

  • Morin, J., Wiktorsson, S., Marlow, T., Olesen, P. J., Skoog, I., & Waern, M. (2013). Alcohol use disorder in elderly suicide attempters: a comparison study. The American Journal of Geriatric Psychiatry, 21(2), 196–203. https://doi.org/10.1016/j.jagp.2012.10.020.

    Article  PubMed  Google Scholar 

  • Mosolov, S. N., Kostyukova, E. G., & Kuzavkova, M. V. (2008). Bipolyarnoe affektivnoe rasstroystvo: diagnostika i terapiya [bipolar disorder: diagnosis and therapy]. Moscow, Russia: MEDpressinform (in Russ.).

  • Nabavi, B., Mitchell, A. J., & Nutt, D. (2015). A lifetime prevalence of comorbidity between bipolar affective disorder and anxiety disorders: A meta-analysis of 52 interview-based studies of psychiatric population. EBioMedicine, 2(10), 1405–1419. https://doi.org/10.1016/j.ebiom.2015.09.006.

    Article  PubMed  PubMed Central  Google Scholar 

  • Oquendo, M. A., Currier, D., Liu, S., Hasin, D., Grant, B., & Blanco, C. (2010). Increased risk for suicidal behavior in comorbid bipolar disorder and alcohol use disorders. Journal of Clinical Psychiatry, 71(7), 902–909. https://doi.org/10.4088/JCP.09m05198gry.

    Article  Google Scholar 

  • Orui, M., Kawakami, N., Iwata, N., Takeshima, T., & Fukao, A. (2011). Lifetime prevalence of mental disorders and its relationship to suicidal ideation in a Japanese rural community with high suicide and alcohol consumption rates. Environmental Health and Preventive Medicine, 16, 384–389. https://doi.org/10.1007/s12199-011-0209-y.

    Article  PubMed  PubMed Central  Google Scholar 

  • Perugi, G., Angst, J., Azorin, J. M., Bowden, C., Vieta, E., & Young, A. H. (2013). Is comorbid borderline personality disorder in patients with major depressive episode and bipolarity a developmental subtype? Findings from the international BRIDGE study. Journal of Affective Disorders, 144(1–2), 72–78. https://doi.org/10.1016/j.jad.2012.06.008.

    Article  PubMed  Google Scholar 

  • Rehm, J., Allamani, A., Aubin, H. J., Della Vedova, R., Elekes, Z., Frick, U., et al. (2015). People with alcohol use disorders in specialized care in eight different European countries. Alcohol and Alcoholism, 50(3), 310–318. https://doi.org/10.1093/alcalc/agv009.

    Article  PubMed  Google Scholar 

  • Schuch, J. J., Roest, A. M., Nolen, W. A., Penninx, B. W., & de Jonge, P. (2014). Gender differences in major depressive disorder: results from the Netherlands study of depression and anxiety. Journal of Affective Disorders, 56, 156–163. https://doi.org/10.1016/j.jad.2013.12.011.

    Article  Google Scholar 

  • Simhandl, C., Radua, J., König, B., & Amann, B. L. (2016). Prevalence and impact of comorbid alcohol use disorder in bipolar disorder: a prospective follow-up study. Australian and New Zealand Journal of Psychiatry, 50(4), 345–351.

    Article  Google Scholar 

  • Terra, M. B., Barros, H. M., Stein, A. T., Figueira, I., Jorge, M. R., Palermo, L. H., et al. (2006). Social anxiety disorder in 300 patients hospitalized for alcoholism in Brazil: High prevalence and undertreatment. Comprehensive Psychiatry, 47(6), 463–467.

    Article  Google Scholar 

  • Vasilieva, S. N. (2010). Clinical-dynamic characteristics of depressive disorders comorbid with anxiety disorders [supplemental material]. European Psychiatry, 25, 225. https://doi.org/10.1016/S0924-9338(10)70225-X.

    Article  Google Scholar 

  • Zimmerman, M., Martinez, J. H., Young, D., Chelminski, I., & Dalrymple, K. (2013). Severity classification on the Hamilton depression rating scale. Journal of Affective Disorders, 150(2), 384–388. https://doi.org/10.1016/j.jad.2013.04.028.

    Article  PubMed  Google Scholar 

  • Zimmermann, P., Zardi, G., Lehmann, M., Zeder, C., Amrhein, N., Frossard, E., & Bucher, M. (2003). Engineering the root-soil interface via targeted expression of a synthetic phytase gene in trichoblasts. Plant Biotechnology Journal, 1(5), 353–360.

    Article  CAS  Google Scholar 

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Authors and Affiliations

  1. Tomsk National Research Medical Center of the Russian Academy of Sciences, Mental Health Research Institute of Tomsk, Aleutskaya Street 4, 634014, Tomsk, Russia

    Svetlana N. Vasilieva, German G. Simutkin, Evgeny D. Schastnyy & Nikolay A. Bokhan

  2. Department of Psychiatry, Narcology and Psychotherapy, Siberian State Medical University, Tomsk, Russia

    Nikolay A. Bokhan

  3. Department of Psychotherapy and Psychological Counseling of the Faculty of Psychology, National Research Tomsk State University, Tomsk, Russia

    Nikolay A. Bokhan

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  1. Svetlana N. Vasilieva
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  2. German G. Simutkin
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  3. Evgeny D. Schastnyy
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  4. Nikolay A. Bokhan
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Correspondence to Svetlana N. Vasilieva.

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Vasilieva, S.N., Simutkin, G.G., Schastnyy, E.D. et al. Clinical-Dynamic Features of Affective Disorders Comorbid with Alcohol Dependence. Int J Ment Health Addiction 19, 1443–1451 (2021). https://doi.org/10.1007/s11469-020-00234-y

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