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Neuropsychological Impairment and Relapse following Inpatient Detoxification in Severe Alcohol Dependence

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Abstract

The aim of the study was to examine the relationship between neuropsychological impairment in severe alcohol dependence and relapse. This was assessed following inpatient detoxification over a period of three months. Participants were tested on measures of neuropsychological functioning at the end of a seven to ten day stay in an inpatient alcohol detoxification unit. Participants were followed up three months later by telephone to ascertain the number of days in which alcohol was consumed during this period using the Timeline Follow Back procedure (TLFB). A correlation and regression design was used to analyse results. An inpatient alcohol detoxification unit. Thirty-four residents in an inpatient alcohol detoxification unit. Executive dysfunction during detoxification was found to predict number of days drinking in the three months following discharge. Neuropsychological impairment, and specifically executive dysfunction, appears to be a significant barrier to ability to remain abstinent from alcohol following a period of detoxification. Given the high rates of relapse found within the current study it suggests that the cognitive domains that executive functioning describe are particularly relevant in facilitating abstinence in alcohol dependence.

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References

  • Bates, M. E., Pawlak, A. P., Tonigan, J. S., & Buckman, J. F. (2006). Cognitive impairment influences drinking outcome by altering therapeutic mechanisms of change. Psychology of Addictive Behaviors, 20, 241–253.

    Article  PubMed  Google Scholar 

  • Benson, D. F., & Ardila, A. (1996). Aphasia: A clinical perspective. New York: Oxford University Press.

    Google Scholar 

  • Benton, A. L., Hamsher, K., & Sivan, A. B. (1983). Multilingual aphasia examination (3rd ed.). Iowa City: AJA Associates.

    Google Scholar 

  • Blume, A. W., Schmalinga, K. B., & Marlatt, A. G. (2005). Memory, executive cognitive function, and readiness to change drinking behavior. Addictive Behaviors, 30, 301–314.

    Article  PubMed  Google Scholar 

  • Brown, E. S., Bobadilla, L., Nejtek, V. A., Perantie, D., Dhillon, H., & Frol, A. (2003). Open-label nefazodone in patients with a major depressive episode and alcohol dependence. Progress in Neuro-Psychopharmacology and Biological Psychiatry, 4, 681–685.

    Article  Google Scholar 

  • Cohen, J. (1992). A power primer. Psychological Bulletin, 112, 155–159.

    Article  PubMed  CAS  Google Scholar 

  • Cordosi, D. M. (2004). Cognitive effects of methamphetamine dependence and combined methamphetamine/alcohol dependence: a cross-gender study. Dissertation Abstracts International: Section B: The Sciences and Engineering, 65, 3149–3165.

    Google Scholar 

  • Davies, S. J. C., Pamdit, S. A., Feeney, A., Stevenson, B. J., Kerwin, R. W., Nutt, D. J., et al. (2005). Is there cognitive impairment in clinically ‘healthy’ abstinent alcohol dependence? Alcohol & Alcoholism, 40(6), 498–503.

    Article  Google Scholar 

  • Giancola, P. R. (2007). The underlying role of aggressivity in the relation between executive functioning and alcohol consumption. Addictive Behaviors, 32, 765–783.

    Article  PubMed  Google Scholar 

  • Ihara, H., Berrios, G. E., & London, M. (2000). Group and case study of the dysexecutive syndrome in alcoholism without amnesia. Journal of Neurology, Neurosurgery, and Psychiatry, 68, 731–737.

    Article  PubMed  CAS  Google Scholar 

  • Kopelman, M. D. (1995). The Korsakoff Syndrome. British Journal of Psychiatry, 166, 154–173.

    Article  PubMed  CAS  Google Scholar 

  • Kushner, M. G., Abrams, K., Thuras, P., Hanson, K. L., Brekke, M., & Sletten, S. (2005). Follow-up study of anxiety disorder and alcohol dependence in comorbid alcoholism treatment patients. Alcoholism: Clinical and Experimental Research, 29, 334–354.

    Article  Google Scholar 

  • Leber, W. R., Jenkins, R., & Parsons, O. A. (1981). Recovery of visual-spatial learning and memory in chronic alcoholics. Journal of Clinical Psychology, 37, 192–197.

    Article  PubMed  CAS  Google Scholar 

  • Lezak, M. (1995). Neuropsychological assessment (3rd ed.). Oxford University Press.

  • Lysaker, P. H., Bryson, G. J., Lancaster, R. S., Evans, J. D., & Bell, M. D. (2002). Insight in schizophrenia: associations with executive function and coping style. Schizophrenia Research, 59, 41–47.

    Article  Google Scholar 

  • Medina, K. L., & Shear, P. K. (2007). Anxiety, depression & behavioral symptoms of executive dysfunction in ecstasy users: contributions of polydrug use. Drug and Alcohol Dependence, 87, 303–311.

    Article  PubMed  Google Scholar 

  • Miller, L. (1991). Predicting relapse and recovery in alcoholism and addiction: neuropsychology, personality, and cognitive style. Journal of Substance Abuse Treatment, 8, 277–291.

    Article  PubMed  CAS  Google Scholar 

  • Moriyama, Y., Mimura, M., Kato, M., Yoshino, A., Hara, T., Kashima, H., et al. (2002). Executive dysfunction and clinical outcome in chronic alcoholics. Alcoholism: Clinical and Experimental Research, 26, 1239–1244.

    Article  Google Scholar 

  • Moselhy, H. F., Georgiou, G., & Kahn, A. (2001). Frontal lobe changes in alcoholism: a review of the literature. Alcohol and Alcoholism, 36, 357–368.

    Article  PubMed  CAS  Google Scholar 

  • Noel, X., Van der Linden, M., Schmidt, N., Sferrazza, R., Hanak, C., & Le Bon, O. (2001). Supervisory attentional system in nonamnesic alcoholic men. Archives of General Psychiatry, 58, 1152–1158.

    Article  PubMed  CAS  Google Scholar 

  • Nys, G. M. S., van Zandvoort, M. J. E., de Kort, P. L. M., Jansen, B. P. W., de Haan, E. H. F., & Kappelle, L. J. (2007). Cognitive disorders in acute stroke: prevalence and clinical determinants. Cerebrovascular Diseases, 23, 408–416.

    Article  PubMed  CAS  Google Scholar 

  • Osterrieth, P. A. (1944). Le test de copie d’une figure complex: contribution a l’etude de la perception et de la memoire. Archives de Psychologie, 30, 286–356.

    Google Scholar 

  • Parsons, O. A. (1998). Neurocognitive deficits in alcoholics and social drinkers: a continuum? Alcoholism: Clinical and Experimental Research, 22, 954–961.

    CAS  Google Scholar 

  • Rey, A. (1941). L’examinen psychologique dans les cas d’encephalopathie traumatique. Archives de Psychologie, 28, 286–340.

    Google Scholar 

  • Rey, A. (1958). L’examen Clinique en Psychologie. Paris: PUF.

    Google Scholar 

  • Rourke, S. B., & Loberg, T. (1996). Neurobehavioral correlates of alcoholism. In I. Grant & K. M. Adam (Eds.), Neuropsychological assessment of neuropsychiatric disorders. New York: Oxford University Press.

    Google Scholar 

  • Ryan, C., & Butters, N. (1986). The neuropsychology of alcoholism. In D. Wedding, A. Horton & J. Webster (Eds.), The neuropsychology handbook: Behavioral and clinical perspectives. New York: Springer.

    Google Scholar 

  • Schade, A., Marquenie, L. A., van Balkom, A. J., de Beurs, E., van Dyck, R., & van den Brink, W. (2003). Do comorbid anxiety disorders in alcohol-dependent patients need specific treatment to prevent relapse? Alcohol and Alcoholism, 38, 255–262.

    Article  PubMed  Google Scholar 

  • Shallice, T. (1988). From neuropsychology to mental structure. Cambridge: Cambridge University Press.

    Book  Google Scholar 

  • Scheurich, A., Muller, M. J., Szegedi, A., Anghelescu, I., Klawe, C., Lorch, B., et al. (2004). Neuropsychological status of alcohol-dependant patients: increased performance through goal-setting instructions. Alcohol and Alcoholism, 39, 119–125.

    Article  PubMed  CAS  Google Scholar 

  • Smith, S., White, J., Nelson, C., Davies, M., Lavers, J., & Sheron, N. (2006). Severe alcohol-induced liver disease and the alcohol dependence syndrome. Alcohol and Alcoholism, 41, 274–277.

    Article  PubMed  Google Scholar 

  • Sobell, L. C., Maisto, S. A., & Sobell, M. B. (1979). Comparison of alcoholics' self-reports of drinking behavior with reports of collateral informants. Journal of Consulting and Clinical Psychology, 47, 106–112.

    Article  PubMed  Google Scholar 

  • Sobell, L. C., Brown, J., Leo, G. I., & Sobell, M. B. (1996). The reliability of the alcohol timeline followback when administered by telephone and by computer. Drug and Alcohol Dependence, 42, 49–54.

    Article  PubMed  CAS  Google Scholar 

  • Solomon, D. A., & Malloy, P. F. (1992). Alcohol, head injury, and neuropsychological function. Neuropsychology Review, 3, 249–280.

    Article  PubMed  CAS  Google Scholar 

  • Spreen, O., & Strauss, E. A. (1998). Compendium of neuropsychological tests. New York: Oxford University Press.

    Google Scholar 

  • Stockwell, T., Murphy, D., & Hodgson, R. (1983). The severity of alcohol dependence questionnaire: its use, reliability and validity. British Journal of Addiction, 78, 145–155.

    Article  PubMed  CAS  Google Scholar 

  • Tapert, S. F., Brown, G. G., Kindermann, S. S., Cheung, E. H., Frank, L. R., & Brown, S. A. (2001). fMRI measurement of brain dysfunction in alcohol-dependent young women. Alcoholism: Clinical & Experimental Research, 25, 236–245.

    Article  CAS  Google Scholar 

  • Taylor, E. M. (1959). Psychological appraisal of children with cerebral defects. Cambridge: Harvard University Press.

    Google Scholar 

  • Tuck, R. R., & Jackson, M. (1991). Social, neurological and cognitive disorders in alcoholics. Medical Journal of Australia, 155, 225–229.

    PubMed  CAS  Google Scholar 

  • Wechsler, D. (1997). Wechsler adult intelligence scale-III. San Antonio: Psychology.

    Google Scholar 

  • World Health Organisation. (1992). International statistical classification of diseases and related health problems (ICD-10). Geneva: WHO.

    Google Scholar 

Download references

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  1. Addiction Psychology Service, NHS Lanarkshire, Torrance House, Motherwell, Scotland, UK

    Fraser Morrison

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  1. Fraser Morrison
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Correspondence to Fraser Morrison.

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Morrison, F. Neuropsychological Impairment and Relapse following Inpatient Detoxification in Severe Alcohol Dependence. Int J Ment Health Addiction 9, 151–161 (2011). https://doi.org/10.1007/s11469-009-9261-x

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  • DOI: https://doi.org/10.1007/s11469-009-9261-x

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