The Rise of a New Psychoactive Agent: Salvia divinorum
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Since the 1990s, there has been a rise in the availability and recreational use of a herbal plant called Salvia divinorum. Numerous internet websites have advertised it for sale as a legal herbal alternative to illegal hallucinogens. Initial data surveying use has indicated many young adults are obtaining and using this herb for its psychoactive properties. Reported methods of ingestion for the plant include chewing, and smoking leaves or fortified extracts. Subjective effects of the plant include, affect changes, psychedelic-like changes in perception, and even loss of consciousness. Although the pharmacological properties and possible antidepressant effects have been studied in recent years, little information is known about potential negative impact resulting from recreational use, and scant information about Salvia divinorum currently exists in the psychological and substance abuse literature. While Salvia divinorum appears to be a substance with some therapeutic potential, it also poses some significant dangers as a substance of varying legal status with a potential for abuse.
KeywordsSalvia divinorum Salvia Drugs of abuse Recreational drugs Hallucinogen Kappa-opioid receptor Salvinorin-A Herbal drugs
- Baggott, M. J., Erowid, E., Erowid, F., & Mendelson, J. E. (2004). Use of salvia divinorum, an unscheduled hallucinogenic plant: A web-based survey of 500 users. Clinical Pharmacology and Therapeutics 75, 72.Google Scholar
- Chavkin, C., Sud, S., Jin, W., Stewart, J., Zjawiony, J. K., Siebert, D. J., et al. (2004). Salvinorin A, an active component of the hallucinogenic sage Salvia divinorum, is a highly efficacious kappa opioid receptor agonist: Structural and functional considerations. The Journal of Pharmacology and Experimental Therapeutics, 308(3), 1197–1203.PubMedCrossRefGoogle Scholar
- Devine, D. P., Leone, P., Pocock, D., & Wise, R. A. (1993). Differential involvement of ventral tegmental mu, delta and kappa opioid receptors in modulation of basal mesolimbic dopamine release: in vivo microdialysis studies. The Journal of Pharmacology and Experimental Therapeutics, 266, 1236–1246.PubMedGoogle Scholar
- Drug Enforcement Administration. (2007). List of drugs and chemicals of concern. Internet website: http://www.deadiversion.usdoj.gov/drugs_concern/salvia_d/salvia_d.htm.
- Epling, C., & Játiva-M, C. D. (1962). A new species of salvia from Mexico. Botanical Museum. Leaflets Harvard University, 20, 75–76.Google Scholar
- Roth, B. L., Baner, K., Westkaemper, R., Siebert, D., Rice, K. C., Steinberg, S., Ernsberger, P., & Rothman R. B. (2002). Salvinorin A: A potent naturally occurring nonnitrogenous kappa opioid selective agonist. Proceedings of the National Academy of Sciences of the USA, 99(18), 11934–11939.PubMedCrossRefGoogle Scholar
- Schaper D. (2006). National Public Radio: Legal, herbal hallucinogenic draws teens, critics. Radio broadcast Washington, DC: NPR.Google Scholar
- Walsh, S. K., Geter-Douglas, B., Strain, E. C., Bigelow, G. E. (2001). Enadoline and butorphanol: Evaluation of k-agonist on cocaine pharmacodynamics and cocaine self-administration in humans. Pharmacology, 299, 147–158.Google Scholar
- Wasson, R. G. (1962). A new Mexican psychotropic drug from the mint family. Botanical Museum Leaflets Harvard University, 20, 77–84.Google Scholar
- Wasson, R. G. (1963). Notes on the present status of ololiuhqui and the other hallucinogens of Mexico. Botanical Museum Leaflets Harvard University, 20, 161–193.Google Scholar
- Zhang, Y., Butelman, E. R., Schlussman, S. D., Ho, A., & Kreek, M. J. (2005). Effects of the plant-derived hallucinogen salvinorin A on basal dopamine levels in the caudate putamen and in a conditioned place aversion assay in mice: Agonist actions at kappa opioid receptors. Psychopharmacology, 179, 551–558.PubMedCrossRefGoogle Scholar