Abstract
Tumors, irregularities, and malignancies of the brain are deemed lethal. If brain cancer detection techniques are executed appropriately, precious lives might be saved. They should have exceptional mobility, precision, response speed, and high sensitivity. By enabling earlier detection and treatment, a brain tumor sensor has the potential to greatly improve the prognosis for patients with brain tumors. Early detection of brain cancers by the sensor enables early treatment and better patient outcomes. This study demonstrates what is regarded to be a step towards reaching these goals. The proposed is a unique biomedical graphene metasurface sensor (GMS) that can reliably detect and differentiate between various brain tissues. For the proposed study, we have included the abnormal brain tissues of several injuries, tumors, and malignant cells. The proposed GMS reports the highest sensitivity of 153.85 GHz/RIU with a figure of merit of 3.98 and a quality factor of 8.54, where the operating frequency is 0.25 to 0.45 THz. The proposed GMS also indicates the linear functionality for resonance frequency and respective specific brain tissue refractive indices. Overall, these performance indicator parameters indicate good performance, and we can therefore state that the developed GMS structure is highly effective and can be applied for the low-cost, timely, and efficient detection of brain tumors.
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References
Ferreira MFS et al (2017) Roadmap on optical sensors. J Opt (United Kingdom) 19(8). https://doi.org/10.1088/2040-8986/aa7419
Surve J, Patel SK, Parmar J (2022) Design of cost-efficient graphene metasurface based pregnancy test with NOR gate realization and parametric optimization. IEEE Sens J 1–1. https://doi.org/10.1109/JSEN.2022.3218797
Daher MG et al (2022) Detection of basal cancer cells using photodetector based on a novel surface plasmon resonance nanostructure employing perovskite layer with an ultra high sensitivity. Plasmonics. https://doi.org/10.1007/s11468-022-01727-3
Aliqab K, Wekalao J, Alsharari M, Armghan A, Agravat D, Patel SK (2023) Designing a graphene metasurface organic material sensor for detection of organic compounds in wastewater. Biosensors 13(8):759. https://doi.org/10.3390/bios13080759
Almawgani AHM et al (2023) A graphene-metasurface-inspired optical sensor for the heavy metals detection for efficient and rapid water treatment. Photonics 10(1):56. https://doi.org/10.3390/photonics10010056
Du H, Li Z, Wang Y, Yang Q, Wu W (2020) Nanomaterial-based optical biosensors for the detection of foodborne bacteria. Food Reviews International. Taylor and Francis Inc. https://doi.org/10.1080/87559129.2020.1740733
Xu W, Xie L, Ying Y (2017) Mechanisms and applications of terahertz metamaterial sensing: a review. Nanoscale 9(37):13864–13878. https://doi.org/10.1039/c7nr03824k
Hu H et al (2016) Far-field nanoscale infrared spectroscopy of vibrational fingerprints of molecules with graphene plasmons. Nat Commun 7. https://doi.org/10.1038/ncomms12334
Abraham E, Younus A, Delagnes JC, Mounaix P (2010) Non-invasive investigation of art paintings by terahertz imaging. Appl Phys A Mater Sci Process 100(3):585–590. https://doi.org/10.1007/s00339-010-5642-z
Yu C, Fan S, Sun Y, Pickwell-Macpherson E (2012) The potential of terahertz imaging for cancer diagnosis: a review of investigations to date. Quant Imaging Med Surg 2(1):33–45. https://doi.org/10.3978/j.issn.2223-4292.2012.01.04
Yang J et al (2021) A terahertz metamaterial sensor used for distinguishing glucose concentration. Results Phys 26. https://doi.org/10.1016/j.rinp.2021.104332
Zhao HZ, Zhou YJ, Cai J, Li QY, Li Z, Xiao ZY (2020) Ultra-high resolution sensing of glucose concentration based on amplified half-integer localized surface plasmons mode. J Phys D Appl Phys 53(9). https://doi.org/10.1088/1361-6463/ab5b4f
Vafapour Z (2019) Polarization-independent perfect optical metamaterial absorber as a glucose sensor in food industry applications. IEEE Trans Nanobioscience 18(4):622–627. https://doi.org/10.1109/TNB.2019.2929802
Cherkasova O, Nazarov M, Shkurinov A (2016) Noninvasive blood glucose monitoring in the terahertz frequency range. Opt Quantum Electron 48(3). https://doi.org/10.1007/s11082-016-0490-5
Otsuji T (2015) Trends in the research of modern terahertz detectors: plasmon detectors. IEEE Trans Terahertz Sci Technol 5(6):1110–1120
Balandin AA (2011) Thermal properties of graphene and nanostructured carbon materials. Nat Mater 10(8):569–581. https://doi.org/10.1038/nmat3064
Wu X et al (2018) Boosting carrier mobility of synthetic few layer graphene on SiO2 by interlayer rotation and decoupling. Adv Mater Interfaces 5(14). https://doi.org/10.1002/admi.201800454
Yu N, Capasso F (2014) Flat optics with designer metasurfaces. Nat Mater 13(2):139–150. https://doi.org/10.1038/nmat3839
Patel SK, Surve J, Prajapati P, Taya SA (2022) Design of an ultra-wideband solar energy absorber with wide-angle and polarization independent characteristics. Opt Mater (Amst) 131:112683. https://doi.org/10.1016/j.optmat.2022.112683
Patel SK, Surve J, Parmar J, Natesan A, Katkar V (2022) Graphene-based metasurface refractive index biosensor for hemoglobin detection: machine learning assisted optimization. IEEE Trans Nanobioscience 1–1. https://doi.org/10.1109/TNB.2022.3201237
Ding P et al (2021) Graphene metasurface for broadband, wide-angle and polarization-insensitive carpet cloak. Opt Mater (Amst) 121. https://doi.org/10.1016/j.optmat.2021.111578
Alexander K, Savostianova NA, Mikhailov SA, Van Thourhout D, Kuyken B (2018) Gate-tunable nonlinear refraction and absorption in graphene-covered silicon nitride waveguides. ACS Photonics 5(12):4944–4950. https://doi.org/10.1021/acsphotonics.8b01132
Tiwari A, Srivastava S, Pant M (2020) Brain tumor segmentation and classification from magnetic resonance images: review of selected methods from 2014 to 2019. Pattern Recognit Lett 131:244–260. https://doi.org/10.1016/j.patrec.2019.11.020
Nadeem MW et al (2020) Brain tumor analysis empowered with deep learning: a review, taxonomy, and future challenges. Brain Sciences 10(2). https://doi.org/10.3390/brainsci10020118
Logeswari T, Karnan M (2010) An improved implementation of brain tumor detection using segmentation based on hierarchical self organizing map. Int J Comput Theory Eng 591–595. https://doi.org/10.7763/ijcte.2010.v2.207
Schonberg DL, Lubelski D, Miller TE, Rich JN (2013) Brain tumor stem cells: molecular characteristics and their impact on therapy. Mol Aspects Med 39:82–101. https://doi.org/10.1016/j.mam.2013.06.004
Cheung AT et al (2019) Impact of brain tumor and its treatment on the physical and psychological well-being, and quality of life amongst pediatric brain tumor survivors. Eur J Oncol Nurs 41:104–109. https://doi.org/10.1016/j.ejon.2019.06.003
Law N et al (2011) Cerebello-thalamo-cerebral connections in pediatric brain tumor patients: impact on working memory. Neuroimage 56(4):2238–2248. https://doi.org/10.1016/j.neuroimage.2011.03.065
Chahal PK, Pandey S, Goel S (2020) A survey on brain tumor detection techniques for MR images. Multimed Tools Appl 79(29–30):21771–21814. https://doi.org/10.1007/s11042-020-08898-3
Abdullah AA, Chize BS, Nishio Y (2012) Implementation of an improved cellular neural network algorithm for brain tumor detection. In: 2012 International Conference on Biomedical Engineering, ICoBE 2012. pp 611–615. https://doi.org/10.1109/ICoBE.2012.6178990
Rupp F, Jedamzik R, Bartelmess L, Petzold U (2021) The modern way of refractive index measurement of optical glass at SCHOTT. p 8. https://doi.org/10.1117/12.2597023
Raeen MS, Nella A (2023) A plasmonic metamaterial flexible absorber design and analysis in optical regime. Opt Quantum Electron 55(8). https://doi.org/10.1007/s11082-023-04968-6
Raeen MS, Nella A, Maheswar R (2023) A fourfold star petal–shaped polarization-insensitive broadband plasmonic metamaterial absorber. Plasmonics 18(3):1059–1074. https://doi.org/10.1007/s11468-023-01815-y
Patel SK et al (2023) Graphene-based H-shaped biosensor with high sensitivity and optimization using ML-based algorithm. Alexandria Eng J 68:15–28. https://doi.org/10.1016/j.aej.2023.01.002
Salski B (2014) An FDTD model of graphene intraband conductivity. IEEE Trans Microw Theory Tech 62(8):1570–1578. https://doi.org/10.1109/TMTT.2014.2331620
Yan H et al (2011) Infrared spectroscopy of wafer-scale graphene. ACS Nano 5(12):9854–9860. https://doi.org/10.1021/nn203506n
Jadeja R, Surve J, Parmar T, Patel SK, Al-Zahrani FA (2023) Detection of peptides employing a THz metasurface based sensor. Diam Relat Mater 109675. https://doi.org/10.1016/j.diamond.2022.109675
Patel SK et al (2022) Terahertz metasurface-based refractive index sensor for amino acid detection: a numerical approach. IEEE Trans Nanobioscience 1–1. https://doi.org/10.1109/TNB.2022.3222446
Liu PY et al (2016) Cell refractive index for cell biology and disease diagnosis: past, present and future. Lab Chip 16(4):634–644. https://doi.org/10.1039/c5lc01445j
Biwas TK, Gupta AK (2002) Retrieval of true color of the internal organ of CT images and attempt to tissue characterization by refractive index: initial experience. Indian J Radiol Imaging 12(2):169–178
COMSOL Multiphysics® v. 6.0
Mason JC, Handscomb DC (2002) Chebyshev polynomials
Ramanujam NR et al (2019) Enhanced sensitivity of cancer cell using one dimensional nano composite material coated photonic crystal. Microsyst Technol 25(1):189–196. https://doi.org/10.1007/s00542-018-3947-6
White IM, Fan X (2008) On the performance quantification of resonant refractive index sensors. Opt Express 16(2):1020. https://doi.org/10.1364/OE.16.001020
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Researchers Supporting Project number (RSPD2023R654), King Saud University, Riyadh, Saudi Arabia.
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Researchers Supporting Project number (RSPD2023R654), King Saud University, Riyadh, Saudi Arabia.
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Conceptualization: Osamah Alsalman, Shobhit K. Patel; methodology: Osamah Alsalman, Shobhit K. Patel, and Jacobe Wekaleo; software: Jacob Wekalao, and Shobhit K. Patel; validation, Dhruvik Agravat, U. Arun Kumar, and Juveriya Parmar; writing—original draft preparation: all authors; writing—review and editing: all authors; all authors have read and agreed to the published version of the manuscript.
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Alsalman, O., Wekalao, J., Arun Kumar, U. et al. Design of Split Ring Resonator Graphene Metasurface Sensor for Efficient Detection of Brain Tumor. Plasmonics 19, 523–532 (2024). https://doi.org/10.1007/s11468-023-02002-9
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DOI: https://doi.org/10.1007/s11468-023-02002-9