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Investigation of the Plasmonic Interaction of Gold Nanoparticles Toward Plasmonic Photothermal Therapeutics

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Abstract

Plasmonic interaction of nanoparticles located in close proximity, embedded in breast tissue, is simulated for estimating the optical characteristics like optical absorption cross-section, plasmonic wavelength as well as full-width half maxima (FWHM). The computations are done for the monomers, homodimers, and heterodimers of spherical and rod-shaped gold nanoparticles considering various interparticle spacings for gold nanospheres and the interparticle spacing as well as the orientation for gold nanorods (GNRs). The results indicate that for the spherical dimer, with the change in interparticle spacing from 1 to 20 nm, the peak absorption cross-section decreases by 43%. Whereas for the GNRs, the absorption cross-section increases/decreases, within 9–18%, depending on the homodimer or heterodimer configuration. Furthermore, secondary peaks for the absorption cross-section are obtained within wavelengths of 630–940 nm due to antibonding modes for GNR heterodimers. For GNR heterodimer located end-to-end, this secondary peak for the absorption cross-section appears at 780 nm irrespective of interparticle spacing within 1–5 nm. The absorption coefficient is considerably dependent on the configuration and proximity of GNRs located within the tissue. While FWHM is not significantly influenced by GNRs configuration and interparticle spacing. For interparticle spacing from 1 to 20 nm, the plasmonic wavelength shifts by 38 nm for the spherical dimer and by 35–86 nm for various GNR dimers. The findings of this study are useful for plasmonic photothermal therapeutics as the heat generation is governed by the resulting absorption cross-section due to plasmonic coupling of the closely spaced and different orientations of the nanoparticles.

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Acknowledgements

Authors acknowledge CSIR-Central Scientific Instruments Organisation, Chandigarh, India, for infrastructure support.

Funding

Vikas received the fellowship from the Indian Council of Medical Research, Delhi, India, vide grant number #5/3/8/83/ITR-F/2020-ITR.

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Authors and Affiliations

  1. Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, 201002, India

    Vikas, Raj Kumar & Sanjeev Soni

  2. Biomedical Instrumentation Division, CSIR — Central Scientific Instruments Organisation, Sector-30C, Chandigarh, 160030, India

    Vikas & Sanjeev Soni

  3. Optical Devices & Systems Division, CSIR — Central Scientific Instruments Organisation, Sector-30C, Chandigarh, 160030, India

    Raj Kumar

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  1. Vikas
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  2. Raj Kumar
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  3. Sanjeev Soni
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Contributions

Vikas and Sanjeev Soni contributed to the study conception and design. Vikas performed the simulation and prepared the first draft of the manuscript. Sanjeev Soni & Raj Kumar edited and reviewed the manuscript.

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Correspondence to Sanjeev Soni.

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Vikas, Kumar, R. & Soni, S. Investigation of the Plasmonic Interaction of Gold Nanoparticles Toward Plasmonic Photothermal Therapeutics. Plasmonics 17, 107–118 (2022). https://doi.org/10.1007/s11468-021-01506-6

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  • DOI: https://doi.org/10.1007/s11468-021-01506-6

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