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Study on Trace Sample of Chronic Skin Ulcer with a Symmetrical Optical Waveguide-Based Surface Plasmon Resonance Biosensor

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Abstract

A prototype of symmetrical optical waveguide (SOW)-based surface plasmon resonance (SPR) sensing system is developed. Based on a polydopamine and matrix metalloproteinase-9 (MMP-9) antibody sensing protocol, trace samples of secretions from the chronic skin ulcer are detected with the SPR sensing system, and the detection results are compared with conventional enzyme-linked immunosorbent assay (ELISA) results, showing the clinical utility of the SPR detector. Considering the capability of trace sample and high-throughput detections, the SOW-based SPR sensing system has great potential in other clinical applications.

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References

  1. Sen CK, Gordillo GM, Roy S, Kirsner R, Lambert L, Hunt TK, Gottrup F, Gurtner GC, Longaker MT (2009) Human skin wounds: a major and snowballing threat to public health and the economy. Wound Repair Regen 17(6):763–771

    Article  Google Scholar 

  2. Ewan AJ Wilkinson (2014) Oral zinc for arterial and venous leg ulcers. Cochrane Database of Systematic Reviews, Issue 9

  3. Abbade LPF, Lastoria S (2005) Venous ulcer: epidemiology, physiopathology, diagnosis and treatment. Int J Dermatol 44:449–456

    Article  Google Scholar 

  4. Dhall S, Do D, Garcia M, Wijesinghe DS, Brandon A et al (2014) A novel model of chronic wounds: importance of redox imbalance and biofilm-forming bacteria for establishment of chronicity. PLoS ONE 9(10):e109848

    Article  Google Scholar 

  5. Kahle B, Hermanns HJ, Gallenkemper G (2011) Evidence-based treatment of chronic leg ulcers. Deutsches Arzteblatt Int 108(14):231–237

    Google Scholar 

  6. China forum on diabetic foot and related diseases (2012) http://www.a1cedu.org/index.php/main_index_wid_13

  7. Engvall E, Perlmann P (1971) Enzyme-linked immunosorbent assay (ELISA) quantitative assay of immunoglobulin G. Immunochemistry 8(9):871–874

    Article  CAS  Google Scholar 

  8. Dalton SJ, Whiting CV, Bailey JR, Mitchell DC, Tarlton JF (2007) Mechanisms of chronic skin ulceration linking lactate, transforming growth factor-β, vascular endothelial growth factor, collagen remodeling, collagen stability, and defective angiogenesis. J Investig Dermatol 127:958–968

    Article  CAS  Google Scholar 

  9. Serra R, Buffone G, Falcone D (2013) Chronic venous leg ulcers are associated with high levels of metalloproteinases-9 and neutrophil gelatinase-associated lipocalin. Wound Repair Regen 21(3):395–401

    Article  Google Scholar 

  10. Tuchin VV (2010) Handbook of photonics for biomedical science, CRC press, Taylor & Francis Group

  11. Homola J (2008) Surface plasmon resonance sensors for detection of chemical and biological species. Chem Rev 108:462–493

    Article  CAS  Google Scholar 

  12. Vikholm-Lundin I, Piskonen R, Albers WM (2007) Hybridisation of surface-immobilised single-stranded oligonucleotides and polymer monitored by surface plasmon resonance. Biosens Bioelectron 22:1323–1329

    Article  CAS  Google Scholar 

  13. Piliarik M, Parova L, Homola J (2009) High-throughput SPR sensor for food safety. Biosens Bioelectron 24:1399–1404

    Article  CAS  Google Scholar 

  14. Yuk JS, Kim HS, Jung JW, Jung SH, Lee SJ, Kim WJ, Han JA, Kim YM, Ha KS (2006) Analysis of protein interactions on protein arrays by a novel spectral surface plasmon resonance imaging. Biosens Bioelectron 21:1521–1528

    Article  CAS  Google Scholar 

  15. Chong XY, Liu L, Liu ZY, Ma SH, Guo J, Ji YH, He YH (2013) Detect the hybridization of single-stranded DNA by parallel scan spectral surface plasmon resonance imaging. Plasmonics 8:1185–1191

    Article  CAS  Google Scholar 

  16. Liu L, He YH, Zhang Y, Ma SH, Ma H, Guo JH (2008) Parallel scan spectral surface plasmon resonance imaging. Appl Opt 47(30):5616–5621

    Article  CAS  Google Scholar 

  17. Liu L, Chen XL, Liu ZY, Ma SH, Du C, He YH, Guo JH (2012) Polarization interference interrogation of angular surface plasmon resonance sensors with wide metal film thickness tolerance. Sensors Actuators B Chem 173:218–224

    Article  CAS  Google Scholar 

  18. Liu L, Hu ZX, Ma SH, Zhang Y, He YH, Guo JH (2010) Detection of methane by a surface plasmon resonance sensor based on polarization interferometry and angle modulation. Opt Lasers Eng 48:1182–1185

    Article  Google Scholar 

  19. Liu ZY, Peng Q, Shi H, Sun SQ, Guo J, Wang XX, Liu L, Ji YH, Guo JH, Ma H, He YH (2013) MgF2-Au-MgF2-polydopamine based surface plasmon resonance sensor and its application in biomedical systems. Anal Methods 5(22):6306–6311

    Article  CAS  Google Scholar 

  20. Shi H, Liu ZY, Wang XX, Guo J, Liu L, Luo L, Guo JH, Ma H, Sun SQ, He YH (2013) A symmetrical optical waveguide based surface plasmon resonance biosensing system. Sensors Actuators B Chem 185:91–96

    Article  CAS  Google Scholar 

  21. Liu L, Guo J, He YH, Zhang PF, Zhang YL, Guo JH (2014) Study on the despeckle methods in angular surface plasmon resonance imaging sensors. Plasmonics in press. doi:10.1007/s11468-014-9859-0

  22. Maier JS, Walker SA, Fantini S, Franceschini MA, Gratton E (1994) Possible correlation between blood glucose concentration and the reduced scattering coefficient of tissues in the near infrared. Opt Lett 19:2062–2064

    Article  CAS  Google Scholar 

  23. Homola J, Piliarik M (2006) In: Homola J (ed) Surface plasmon resonance based sensors. Springer, Berlin

    Chapter  Google Scholar 

  24. Mohan R, Chintala SK, Jung JC, Villar WVL, McCabe F, Russo LA, Lee Y, McCarthy BE, Wollenberg KR, Jester JV, Wang M, Welgus HG, Shipley JM, Senior RM, Fini ME (2002) Matrix metalloproteinase gelatinase B (MMP-9) coordinates and effects epithelial regeneration. J Biol Chem 277(3):2065–2072

    Article  CAS  Google Scholar 

  25. Reiss MJ, Han YP, Garcia E, Goldberg M, Yu H, Garner WL (2010) Matrix metalloproteinase-9 delays wound healing in a murine wound model. Surgery 147(2):295–302

    Article  Google Scholar 

  26. Kyriakides TR, Wulsin D, Skokos EA, Fleckman P, Pirrone A, Shipley JM, Senior RM, Bornstein P (2009) Mice that lack matrix metalloproteinase-9 display delayed wound healing associated with delayed reepithelization and disordered collagen fibrillogenesis. Matrix Biol 28(2):65–73

    Article  CAS  Google Scholar 

  27. Liu Y, Min D, Bolton T, Nube V, Twigg SM, Yue DK, McLennan SV (2009) Increased matrix metalloproteinase-9 predicts poor wound healing in diabetic foot ulcers. Diabetes Care 32(1):117–119

    Article  CAS  Google Scholar 

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Acknowledgments

This research was made possible with the financial support from NSFC China (grant 61361160416, 61308119, 61275188) and Administration of Traditional Chinese Medicine of Beijing (grant WZF2012-21).

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Authors and Affiliations

  1. Beijing Hospital of Traditional Chinese Medicine, Capital Medical University, Beijing, 100010, China

    Han Lin, Leping Wang, Jianxun Dong, Xuying Xu, Xuhui Zhang & Qingquan Liu

  2. Institute of Green Chemistry and Energy, Graduate School at Shenzhen, Tsinghua University, Shenzhen, 518055, China

    Le Liu

  3. Shenzhen Key Laboratory for Minimal Invasive Medical Technologies, Institute of Optical Imaging and Sensing, Graduate School at Shenzhen, Tsinghua University, Shenzhen, 518055, China

    Le Liu, Lin Zhang & Qiang Huang

Authors
  1. Han Lin
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  2. Leping Wang
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  3. Jianxun Dong
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  4. Xuying Xu
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  5. Le Liu
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  6. Lin Zhang
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  7. Qiang Huang
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  8. Xuhui Zhang
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  9. Qingquan Liu
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Correspondence to Le Liu or Qingquan Liu.

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Lin, H., Wang, L., Dong, J. et al. Study on Trace Sample of Chronic Skin Ulcer with a Symmetrical Optical Waveguide-Based Surface Plasmon Resonance Biosensor. Plasmonics 10, 1631–1637 (2015). https://doi.org/10.1007/s11468-015-9983-5

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  • DOI: https://doi.org/10.1007/s11468-015-9983-5

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