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Carbohydrate–Lectin Interaction on Graphene-Coated Surface Plasmon Resonance (SPR) Interfaces

Plasmonics volume 9, pages 677–683 (2014)Cite this article

Abstract

The paper describes the detection of carbohydrate–lectin interaction on graphene-on-metal surface plasmon resonance (SPR) interfaces. Graphene-coated gold-based SPR interfaces were formed through the transfer of large-area graphene grown by chemical vapor deposition (CVD) on polycrystalline Cu foils. The method allowed successful transfer of single- and double-layered graphene sheets onto the SPR interfaces in a reproducible manner. Functionalization of the graphene interface with mannose was achieved by simple immersion into a mannose aqueous solution (100 mM), resulting in noncovalent interactions between the aromatic ring structure of graphene and mannose. The utility of the carbohydrate-modified graphene-on-gold interface for the selective and sensitive detection of carbohydrate–lectin interactions was demonstrated using model lectins from Lens culinaris (LC) and Triticum vulgaris (TV). While LC lectin binds specifically to mannopyranoside units, TV lectin has an affinity for N-acetyl glucosamine and sialic acid residues.

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Acknowledgments

R.B. and S.S. gratefully acknowledge the financial support from the Centre National de Recherche Scientifique (CNRS), the University Lille 1, Nord Pas de Calais region, and the European Regional Development Fund (INTERREG IVa FW1.1.9 “Plasmobio” project). S.S. thanks the Institut Universitaire de France (IUF) for the financial support. P.S. gratefully acknowledges the financial support from the European Commission through RTN project MATCON (contract no. 238201). This work was partly funded by a grant from the Croatian Ministry of Science, Education and Sports, project 098-0982934-2717. Financial support from the ANR P2N GRACY project is acknowledged.

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Authors and Affiliations

  1. Institut de Recherche Interdisciplinaire (IRI, USR-3078), Université Lille 1, Parc de la Haute Borne, 50 Avenue de Halley, BP 70478, 59658, Villeneuve d’Ascq, France

    Abra Penezic, Palaniappan Subramanian, Rabah Boukherroub & Sabine Szunerits

  2. Division for Marine and Environmental Research, Ruđer Bošković Institute, Bijenička 54, 10000, Zagreb, Croatia

    Abra Penezic & Blaženka Gasparović

  3. Institute of Electronics, Microelectronics and Nanotechnology (IEMN), UMR-CNRS 8520, Université Lille 1, Cité Scientifique, 59655, Villeneuve d’Ascq, France

    Geetanjali Deokar, Dominique Vignaud, Emmanuelle Pichonat & Henri Happy

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  1. Abra Penezic
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  2. Geetanjali Deokar
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  3. Dominique Vignaud
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  4. Emmanuelle Pichonat
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  5. Henri Happy
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  6. Palaniappan Subramanian
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  7. Blaženka Gasparović
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  8. Rabah Boukherroub
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  9. Sabine Szunerits
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Correspondence to Sabine Szunerits.

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Penezic, A., Deokar, G., Vignaud, D. et al. Carbohydrate–Lectin Interaction on Graphene-Coated Surface Plasmon Resonance (SPR) Interfaces. Plasmonics 9, 677–683 (2014). https://doi.org/10.1007/s11468-014-9686-3

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  • DOI: https://doi.org/10.1007/s11468-014-9686-3

Keywords

  • Graphene
  • Surface plasmon resonance
  • Mannose
  • Lectins
  • Biosensors