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Gold Nanoparticle Ring and Hole Structures for Sensing Proteins and Antigen–Antibody Interactions

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Abstract

A new experimentally simple nanosphere lithography method was used to fabricate gold ring and nanohole structures. The method is based on the simultaneous self-assembly of polystyrene microspheres and gold colloids in multilayers, by a vertical deposition method. Dissolution of polystyrene microspheres resulted in the formation of a monolayer, where holes are surrounded by gold nanoparticles. The dependency of the sensitivity of the sensor platform on the size of the holes and their density has been demonstrated. Furthermore, sensing experiments have shown a high sensitivity of the hole structure toward fibrinogen, amyloid-derived diffusible ligands, and a plant protein (AT5G07010.1). It was found that the position and shape of the localized surface plasmon resonance band changed significantly as a result of the antigen–antibody recognition event.

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Authors and Affiliations

  1. Department of Electrical and Computer Engineering, Concordia University, 1515 St. Catherine W, Montreal, Quebec, Canada, H3G 2W1

    F. Fida, S. Badilescu & M. Kahrizi

  2. Department of Biology, Concordia University, 7141 Sherbrooke St W, Montreal, Quebec, Canada, H4B 1R6

    L. Varin

  3. Department of Physics, Concordia University, 7141 Sherbrooke St W, Montreal, Quebec, Canada, H4B 1R6

    Vo-Van Truong

Authors
  1. F. Fida
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  2. L. Varin
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  3. S. Badilescu
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  4. M. Kahrizi
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  5. Vo-Van Truong
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Correspondence to F. Fida.

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Fida, F., Varin, L., Badilescu, S. et al. Gold Nanoparticle Ring and Hole Structures for Sensing Proteins and Antigen–Antibody Interactions. Plasmonics 4, 201–207 (2009). https://doi.org/10.1007/s11468-009-9093-3

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  • DOI: https://doi.org/10.1007/s11468-009-9093-3

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