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Design and evaluation of a novel biopsy needle with hemostatic function

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Abstract

Biopsy is a method commonly used for early cancer diagnosis. However, bleeding complications of widely available biopsy are risky for patients. Safer biopsy will result in a more accurate cancer diagnosis and a decrease in the risk of complications. In this article, we propose a novel biopsy needle that can reduce bleeding during biopsy procedures and achieve stable hemostasis. The proposed biopsy needle features a compact structure and can be operated easily by left and right hands. A predictive model for puncture force and tip deflection based on coupled Eulerian–Lagrangian (CEL) method is developed. Experimental results show that the biopsy needle can smoothly deliver the gelatin sponge hemostatic plug into the tissue. Although the hemostatic plug bends, the overall delivery process is stable, and the hemostatic plug retains in the tissue without being affected by the withdrawal of the needle. Further experiments indicate that the specimens are well obtained and evenly distributed in the groove of the outer needle without scattering. Our proposed design of biopsy needle possesses strong ability of hemostasis, tissue cutting, and tissue retention. The CEL model accurately predicts the peak of puncture force and produces close estimation of the insertion force at the postpuncture stage and tip position.

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Abbreviations

CEL:

Coupled Eulerian–Lagrangian

FEA:

Finite element analysis

ID:

Inner diameter

OD:

Outer diameter

C 10 :

Shear modulus of the tissue

E n :

Young’s modulus of the needle

f :

Frictional resistance

g 1 g 2 :

Relaxation moduli of parts 1 and 2, respectively

G 0 :

Relaxation modulus G(t) evaluated in t = 0

G i :

Relaxation modulus G(t) evaluated in t = τi

G(t):

Relaxation modulus

J :

Elastic volume ratio

k :

Bulk modulus

K :

Stiffness coefficient of spring A

m :

Mass of the slider and inner needle

p :

Hydrostatic pressure

t :

Cutting time

v :

Cutting velocity

W :

Strain energy density

x :

Displacement of slider

µ :

Shear modulus

λ i :

Shield gravity

σ :

Nominal stress

σi :

Nominal stress component

ε :

Principal stain

ε i :

Principal stain component

v n :

Poisson’s ratio of the needle

ρ n :

Density of the needle

ρ t :

Density of the tissue

τ i (i = 1,2):

Relaxation time

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Acknowledgements

This work was partially supported by Shenzhen Key Laboratory of Robotics Perception and Intelligence (Southern University of Science and Technology, China) (Grant No. ZDSYS20200810171800001).

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  1. Equally contributing authors.

Authors and Affiliations

  1. Department of Electronic and Electrical Engineering, Southern University of Science and Technology, Shenzhen, 518055, China

    Xiaolong Zhu, Xiao Xiao, Liang Lu, Wei Xiao, Ziqi Zhao & Max Q.-H. Meng

  2. Department of Mechanical Engineering, University of California, Berkeley, Berkeley, CA, 48072, USA

    Yichi Ma

  3. Department of Electronic Engineering, The Chinese University of Hong Kong, Hong Kong, China

    Hongliang Ren

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  1. Xiaolong Zhu
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Correspondence to Hongliang Ren or Max Q.-H. Meng.

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Zhu, X., Ma, Y., Xiao, X. et al. Design and evaluation of a novel biopsy needle with hemostatic function. Front. Mech. Eng. 18, 22 (2023). https://doi.org/10.1007/s11465-022-0738-7

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