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Chiral ruthenium-SDPs/diamine complexes-catalyzed enantioselective hydrogenation of α-alkyl arylacetones via dynamic kinetic resolution

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Frontiers of Chemistry in China

Abstract

The asymmetric hydrogenation of the conformationally flexible racemic α-substituted acyclic dialkyl ketones via dynamic kinetic resolution (DKR) has been developed by using Ru-SDPs/diamine catalysts. Chiral alcohols were produced in high yields with good to excellent enantioselectivities (85%–97% ee) and diastereoselectivities (up to 97:3). This hydrogenation reaction provided a new approach to the synthesis of the key intermediate of J-104118.

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Authors and Affiliations

  1. State Key Laboratory and Institute of Elemento-organic Chemistry, Nankai University, Tianjin, 300071, China

    Jianhua Xie, Weiling Kong, Xiaocheng Wang, Wenju Bai, Lixin Wang & Qilin Zhou

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  1. Jianhua Xie
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  2. Weiling Kong
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  3. Xiaocheng Wang
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  4. Wenju Bai
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  5. Lixin Wang
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  6. Qilin Zhou
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Corresponding author

Correspondence to Qilin Zhou.

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Xie, J., Kong, W., Wang, X. et al. Chiral ruthenium-SDPs/diamine complexes-catalyzed enantioselective hydrogenation of α-alkyl arylacetones via dynamic kinetic resolution. Front. Chem. China 4, 299–306 (2009). https://doi.org/10.1007/s11458-009-0093-9

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  • DOI: https://doi.org/10.1007/s11458-009-0093-9

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