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6-O-(2-hydroxybutyl)-β-CD as a chiral selector for nonaqueous capillary electrophoretic separation of chiral drugs

  • Research Article
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Frontiers of Chemistry in China

Abstract

6-O-(2-hydroxybutyl)-β-CD, as a new β-cyclodextrin (β-CD) derivative, was successfully synthesized. It was used as a chiral selector to separate six chiral drugs, including propranolol, anisodamine, promethazine, ketoconazole, benzhexol, and fenfluramine in nonaqueous capillary electrophoresis (NACE). The effects of the organic solvent, the electrolytes, the concentrations of cyclodextrin derivatives, and the pH of the buffer on the chiral resolution (Rs) were investigated. The baseline separation of enantiomers, including propranolol (Rs = 2.26), anisodamine (Rs = 2.31), promethazine (Rs = 2.42), ketoconazole (Rs = 2.56), benzhexol (Rs = 3.38), and fenfluramine (Rs = 3.04), could be achieved using a buffer of 100 mmol · Lt−1 citric acid and 50 mmol · Lt−1 Tris (hydroxymethyl) aminomethane (Tris) at pH 4.6 containing 100 mmol · Lt−1 6-O-(2-hydroxybutyl)-β-CD in formamide (FA).

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Authors and Affiliations

  1. School of Chemistry and Chemical Engineering, Shandong University, Jinan, 250100, China

    Wenguo Xing, Yunhe Wei, Ping Yu & Changqiao Zhang

  2. Shandong Analyses and Test Center, Jinan, 250014, China

    Jian Li

Authors
  1. Wenguo Xing
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  2. Yunhe Wei
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  3. Ping Yu
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  4. Changqiao Zhang
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  5. Jian Li
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Correspondence to Yunhe Wei.

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Xing, W., Wei, Y., Yu, P. et al. 6-O-(2-hydroxybutyl)-β-CD as a chiral selector for nonaqueous capillary electrophoretic separation of chiral drugs. Front. Chem. China 4, 396–401 (2009). https://doi.org/10.1007/s11458-009-0038-3

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  • DOI: https://doi.org/10.1007/s11458-009-0038-3

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