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Immunomodulation of artemisinin and its derivatives

  • Review
  • Life & Medical Sciences
  • Published:
Science Bulletin

Abstract

In the 1970s, artemisinin (“qinghaosu” in Chinese), a sesquiterpene lactone with an unusual peroxide bridge, was isolated from Artemisia annua L. It showed promising antimalarial activity, particularly by eliminating parasites resistant to chloroquine. For more than 30 years, artemisinin has contributed to worldwide health as a new type of antimalarial drug. Artemisinin and its analogs, such as dihydroartemisinin, artemether, artesunate, artemiside, artemisone, and arteether, possess not only potent antimalarial activity but also anti-viral, antifungal, anticancer, and anti-inflammatory properties. In this review, we discuss the current understanding of how artemisinin and its analogs affect the immune system and immune-related diseases.

摘要

青蒿素是由中国科学家1972 年首次从复合花序植物黄花蒿中提取的一种含过氧 基团的倍半萜内酯类化合物。它最初用于抗疟治疗, 对脑型疟疾和抗氯喹疟疾有很好的治疗效果, 并且具有速效和低毒的特点。除了抗虐活性外, 青蒿素与它的多种衍还显示出抗病毒、抗真菌、免疫调节以及抗肿瘤等功能。本文综述了目前青蒿素及其衍生物对免疫系统以及免疫相关疾病的影响和研究现状。

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Acknowledgments

This work was supported by the National Natural Science Foundation of China (91529305, 81427805, 81302507, 81302809, 31401611, 81573161, and 81502122), the Ministry of Science and Technology of China (2014AA020524), the CAS/SAFEA International Partnership Program for Creative Research Teams of the Chinese Academy of Sciences, the Science and Technology Commission of Shanghai Municipality (14391901800), and the Key Laboratory of Food Safety Research of INS, SIBS, CAS.

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  1. Key Laboratory of Food Safety Research, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, 200031, China

    Wenbo Yao & Hui Wang

  2. University of Chinese Academy of Sciences, Shanghai, 200031, China

    Wenbo Yao & Hui Wang

  3. Key Laboratory of Food Safety Risk Assessment, Ministry of Health, Beijing, 100022, China

    Hui Wang

  4. School of Life Science and Technology, ShanghaiTech University, Shanghai, 200031, China

    Feng Wang & Hui Wang

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  1. Wenbo Yao
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Yao, W., Wang, F. & Wang, H. Immunomodulation of artemisinin and its derivatives. Sci. Bull. 61, 1399–1406 (2016). https://doi.org/10.1007/s11434-016-1105-z

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