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Leptin in normal physiology and leptin resistance

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  • Life & Medical Sciences
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Science Bulletin

Abstract

Since the discovery of leptin as an adipokine in 1994, much progress has been made in the research about leptin. Circulating leptin binds to leptin receptor, activates STAT3-dependent and STAT3-independent signaling pathways, and plays an effective role in energy homeostasis, neuroendocrine function and metabolism mainly through acting on the central nervous system, especially the hypothalamus. Leptin resistance is considered as a key risk factor for obesity. Various mechanisms have been formulated in order to explain leptin resistance, including impairment in leptin transport, attenuation in leptin signaling, ER stress, inflammation and deficiency in autophagy. Here, we review our current knowledge about leptin action, leptin signaling and leptin resistance, hoping to provide new ideas for the battle against obesity.

摘要

自从1994年瘦素作为一个脂肪细胞因子被发现, 关于瘦素的研究已经取得了很多进展。瘦素与瘦素受体的结合, 在中枢神经系统, 特别是在下丘脑中激活STAT3依赖和非依赖的信号通路, 在维持能量稳态, 神经内分泌作用和代谢等方面都发挥了很重要的作用。瘦素抵抗是肥胖的一个重要危险因素。目前关于瘦素抵抗的机制有很多, 包括瘦素运输受损, 瘦素信号通路削弱, 内质网应激, 炎症和自噬缺陷。在此, 我们对瘦素的功能, 瘦素的信号通路, 瘦素抵抗等进行综述, 希望可以为对抗肥胖的研究提供新的思路。

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Acknowledgments

This work was supported by the National Basic Research Program of China (2013CB530601, 2011CB910201), the National Natural Science Foundation of China (31571401, 81270954, 31030048, 81390350), the Shanghai Rising Star Program (13QH1400800). The Department of Biochemistry and Molecular Biology at Fudan University Shanghai Medical College is supported by the Shanghai Leading Academic Discipline Projects B110 and by “985” Project 985III-YFX0302.

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  1. Key Laboratory of Metabolic Molecular Medicine, The Ministry of Education, Department of Biochemistry and Molecular Biology, Fudan University Shanghai Medical College, Shanghai, 200032, China

    Shufen Li & Xi Li

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SPECIAL TOPIC: Lipid Metabolism and Human Metabolic Disorder.

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Li, S., Li, X. Leptin in normal physiology and leptin resistance. Sci. Bull. 61, 1480–1488 (2016). https://doi.org/10.1007/s11434-015-0951-4

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