Science Bulletin

, Volume 60, Issue 1, pp 86–95 | Cite as

A Connectome Computation System for discovery science of brain

  • Ting Xu
  • Zhi Yang
  • Lili Jiang
  • Xiu-Xia Xing
  • Xi-Nian ZuoEmail author
Article Life & Medical Sciences


Much like genomics, brain connectomics has rapidly become a core component of most national brain projects around the world. Beyond the ambitious aims of these projects, a fundamental challenge is the need for an efficient, robust, reliable and easy-to-use pipeline to mine such large neuroscience datasets. Here, we introduce a computational pipeline—namely the Connectome Computation System (CCS)—for discovery science of human brain connectomes at the macroscale with multimodal magnetic resonance imaging technologies. The CCS is designed with a three-level hierarchical structure that includes data cleaning and preprocessing, individual connectome mapping and connectome mining, and knowledge discovery. Several functional modules are embedded into this hierarchy to implement quality control procedures, reliability analysis and connectome visualization. We demonstrate the utility of the CCS based upon a publicly available dataset, the NKI–Rockland Sample, to delineate the normative trajectories of well-known large-scale neural networks across the natural life span (6–85 years of age). The CCS has been made freely available to the public via GitHub ( and our laboratory’s Web site ( to facilitate progress in discovery science in the field of human brain connectomics.


Connectome Life span Big data Normative charts Discovery science 



This work was partially supported by the National Basic Research Program (973) of China (2015CB351702), the National Natural Science Foundation of China (81220108014, 81471740, 81201153, 81171409, and 81270023), the Key Research Program (KSZD-EW-TZ-002) and the Hundred Talents Program of the Chinese Academy of Sciences. Dr. Xiu-Xia Xing acknowledges the Beijing Higher Education Young Elite Teacher Project (No. YETP1593). Dr. Zhi Yang acknowledges the Foundation of Beijing Key Laboratory of Mental Disorders (2014JSJB03) and the Outstanding Young Researcher Award from Institute of Psychology, Chinese Academy of Sciences (Y4CX062008). We thank all members of the Laboratory for Functional Connectome and Development, Institute of Psychology at CAS and the attendees of the first CCS education course for their helpful feedback and suggestions for the improvement of the CCS.

Conflict of interest

The authors declare that they have no conflicts of interest.


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Copyright information

© Science China Press and Springer-Verlag Berlin Heidelberg 2015

Authors and Affiliations

  • Ting Xu
    • 1
    • 2
    • 3
  • Zhi Yang
    • 1
    • 2
    • 3
  • Lili Jiang
    • 1
    • 2
    • 3
  • Xiu-Xia Xing
    • 4
  • Xi-Nian Zuo
    • 1
    • 2
    • 3
    • 5
    Email author
  1. 1.Key Laboratory of Behavioral Science, Institute of PsychologyChinese Academy of SciencesBeijingChina
  2. 2.Magnetic Resonance Imaging Research Center, Institute of PsychologyChinese Academy of SciencesBeijingChina
  3. 3.Laboratory for Functional Connectome and Development, Institute of PsychologyChinese Academy of SciencesBeijingChina
  4. 4.Department of Applied and Computational Mathematics, College of Applied SciencesBeijing University of TechnologyBeijingChina
  5. 5.Faculty of PsychologySouthwest UniversityChongqingChina

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