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Akt–Oct4 regulatory circuit in pluripotent stem cells

  • Invited Review
  • Cell Biology
  • Published:
Chinese Science Bulletin

Abstract

Oct4 is mainly expressed in embryonic stem cells (ESCs), germline stem cells, and embryonal carcinoma cells (ECCs) and plays an indispensable role in maintaining the pluripotency and self-renewal of these pluripotent stem cells. Akt serine/threonine kinase, a well-established anti-apoptosis and cell survival factor, has also been implicated as an important regulator of stemness. Emerging evidence indicated that Oct4 is reciprocally connected to Akt via a number of routes, and moreover, a direct interaction between Oct4 and Akt has recently been revealed. These components collectively form the Akt–Oct4 regulatory circuit. In this review, we summarize our current knowledge about the Akt–Oct4 regulatory circuit in ESCs and discuss its alterations in ECCs that may underlie the tumorigenesis of pluripotent stem cells.

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Acknowledgments

This work was supported by the National Natural Science Foundation of China (31271465).

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Authors and Affiliations

  1. College of Life Sciences, Zhejiang University, Hangzhou, 310058, China

    Tong Su & Songsong Dan

  2. Chu KoChen Honors College, Zhejiang University, Hangzhou, 310058, China

    Tong Su

  3. State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, 310003, China

    Yingjie Wang

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  1. Tong Su
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  2. Songsong Dan
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  3. Yingjie Wang
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Corresponding author

Correspondence to Yingjie Wang.

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Tong Su and Songsong Dan contributed equally to this work.

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Su, T., Dan, S. & Wang, Y. Akt–Oct4 regulatory circuit in pluripotent stem cells. Chin. Sci. Bull. 59, 936–943 (2014). https://doi.org/10.1007/s11434-014-0131-y

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  • DOI: https://doi.org/10.1007/s11434-014-0131-y

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