Abstract
A catalytic addition of amine N-H bonds to carbodiimides using aluminum chloride as a Lewis acid catalyst is developed. The reaction proceeds under mild conditions without solvent to afford a series of substituted guanidines in good to excellent yields using a wide range of amines as substrates. Evidence of the proposed mechanism is provided by in situ infrared spectroscopy.
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Zhu, X., Xu, F. & Shen, Q. Aluminum chloride: A highly efficient catalyst for addition of amines to carbodiimides to synthesize substituted guanidines. Chin. Sci. Bull. 57, 3419–3422 (2012). https://doi.org/10.1007/s11434-012-5332-7
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DOI: https://doi.org/10.1007/s11434-012-5332-7