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Chinese medicine, flowing blood, biomechanopharmacology and future preventive medicine
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  • Open Access
  • Published: 07 September 2012

Chinese medicine, flowing blood, biomechanopharmacology and future preventive medicine

  • Dong Han1 &
  • FuLong Liao1,2 

Chinese Science Bulletin volume 57, pages 3541–3546 (2012)Cite this article

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Abstract

Activating Blood Circulation to Remove Blood Stasis (ABCRBS) has long been the most fundamental therapeutic principle since the age of Yellow Emperor (circa 2600 BC) in Chinese medicine. Based on bio-responses of blood shear stress, which was not considered in Chinese medicine, we have initiated the merging of biomechanics with pharmacology and Chinese medicine, establishing the new discipline—biomechanopharmacology. Practice of exercise is a simple and self-regulatory way to promote shear stress in the circulation. Interestingly, acupuncture and massage are also linked with shear stress regulation. These procedures are expected to maintain normal functions of endothelial cells (ECs) by regulating shear stress levels of flowing blood. The statement of “Diseases are prevented as blood flow is promoted” by the renowned ancient physician Huatuo, who presented the wise foresight of the efficacy of shear stress, would likely begin a new chapter in preventive pharmacology and medicine in the years to come.

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References

  1. Pennisi E. How did cooperative behavior evolve. Science, 2005, 309: 93–93

    Article  Google Scholar 

  2. Copley A L. The history of clinical hemorheology. Clin Hemorheol, 1985, 5: 765–811

    Google Scholar 

  3. Muller S, Labrador V, Da Isla N, et al. From hemorheology to vascular mechanobiology: An overview. Clin Hemorheol Microcirc, 2004, 30: 185–200

    Google Scholar 

  4. Chiu J-J, Chien S. Effects of disturbed flow on vascular endothelium: Pathophysiological basis and clinical perspectives. Physiol Rev, 2011, 91: 327–387

    Article  Google Scholar 

  5. Krizanac-Bengez L, Mayberg M R, Janigro D. The cerebral vasculature as a therapeutic target for neurological disorders and the role of shear stress in vascular homeostatis and pathophysiology. Neurol Res, 2004, 26: 846–853

    Article  Google Scholar 

  6. Wang Y X, Miao H, Li S, et al. Interplay between integrins and FLK-1 in shear stress-induced signaling. Am J Physiol Cell Physiol, 2002, 283: C1540–C1547

    Google Scholar 

  7. Wang Y X, Chang J, Li Y C, et al. Shear stress and VEGF activate IKK via the Flk-1/Cbl/Akt signaling pathway. Am J Physiol Heart Circ Physiol, 2004, 286: H685–H692

    Article  Google Scholar 

  8. Wang Y, Chang J, Chen K D, et al. Selective adapter recruitment and differential signaling networks by VEGF vs. shear stress. Proc Natl Acad Sci USA, 2007, 104: 8875–8879

    Article  Google Scholar 

  9. Wang J, Chen K J, Weng W L, et al. Research on diagnostic criteria of blood-stasis symptom-complex (in Chinese). J Integrated Trad Chin West Med, 1988, 8: 585–589

    Google Scholar 

  10. Liao F L, Han D, Ouyang Z G, et al. The influences of Ligustrazine and shear stress on PS transformation of endothelial cell membrane investigated by evanescent wave exciting (in Chinese). Acta Biophys Sin, 2003, 19: 92–96

    Google Scholar 

  11. Xie L X, Durairajan S S K, Lu J H, et al. The effect of salvianolic acid B combined with laminar shear stress on TNF-alpha-stimulated adhesion molecule expression in human aortic endothelial cells. Clin Hemorheol Microcirc, 2010, 44: 245–258

    Google Scholar 

  12. O’Brien J R. Shear-induced platelet aggregation. Lancet, 1990. 335: 711–713

    Article  Google Scholar 

  13. Liao F L, Li B. Inhibition of shear-induced platelet aggregation by Chinese herbal medicines. Clin Hemorheol Microcirc, 1997, 17: 315–318

    Google Scholar 

  14. Liao F L, Jiao L G. Ligustrazini, allicin and shear-induced platelet aggregation. Clin Hemorheol Microcirc, 2000, 22: 167–168

    Google Scholar 

  15. Li M, Handa S, Ikeda Y, et al. Specific inhibiting characteristics of tetramethylpyrazine, one of the active ingredients of the Chinese herbal medicine ‘chuanxiong’, on platelet thrombus formation under high shear rates. Thromb Res, 2001, 104: 15–28

    Article  Google Scholar 

  16. Li M, Zhao C, Wong R N S, et al. Inhibition of shear-induced platelet aggregation in rat by tetramethylpyrazine and salvianolic acid B. Clin Hemorheol Microcirc, 2004, 31: 97–103

    Google Scholar 

  17. Ma W, Sun Y, Han D, et al. Cytoskeletal response of microvessel endothelial cells to an applied stress force at the submicrometer scale studied by atomic force microscopy. Micros Res Tech, 2006, 69: 784–793

    Article  Google Scholar 

  18. Han J Y, Fan J Y, Horie Y, et al. Ameliorating effects of compounds derived from Salvia miltiorrhiza root extract on microcirculatory disturbance and target organ injury by ischemia and reperfusion. Pharmacol Ther, 2008, 117: 280–295

    Article  Google Scholar 

  19. Liao F L, Peng J, Li W. Microthrombogenesis induced by rose Bengal under ordinary microscopic illumination. In: Messmer K, Kuble W M, eds. Sixth World Congress for Microcirculation, 1996 Aug 25–30, Munich. Monduzzi Editore, 1996. 479–482

  20. Chen K J, Shi Z X, Practical Works of Blood Stasis Syndrome (in Chinese). Beijing: The People’s Health Publisher, 1999

    Google Scholar 

  21. Lu X Y, Shi D Z, Xu H, et al. Clinical study on effect of xiongshao capsule on restenosis after percutaneous coronary intervention (in Chinese). Chin J Integrated Trad Chin West Med, 2006, 26: 13–17

    Google Scholar 

  22. Xu H, Shi D Z, Chen K J, et al. Clinical effect of xiongshao capsule on preventing restenosis post-PTCA or/and Stenting (in Chinese). Chin J Integrated Trad Chin West Med, 2000, 20: 494–497

    Google Scholar 

  23. Liao F L, Li M, Han D, et al. Biomechanopharmacology: A new borderline discipline. Trends Pharmaco Sci, 2006, 27: 287–289

    Article  Google Scholar 

  24. Kuo T C, Lin C W, Ho F M. The soreness and numbness effect of acupuncture on skin blood flow. Am J Chin Med, 2004, 32: 117–129

    Article  Google Scholar 

  25. Litscher G. Bioengineering assessment of acupuncture, Part 3: Ultrasound. Crit Rev Biomed Eng, 2006, 34: 295–325

    Article  Google Scholar 

  26. Liu Y F, Xu S X, Yan J T, et al. Capillary blood flow with dynamical change of tissue pressure caused by exterior force (in Chinese). J Biomed Eng, 2004, 21: 699–703

    Google Scholar 

  27. Florian J A, Kosky J R, Ainslie K, et al. Heparan sulfate proteoglycan is a mechanosensor on endothelial cells. Circ Res, 2003, 93: E136–E142

    Article  Google Scholar 

  28. Tarbell J M, Weinbaum S, Kamm R D. Cellular fluid mechanics and mechanotransduction. Ann Biomed Eng, 2005, 33: 1719–1723

    Article  Google Scholar 

  29. Milovanova T, Chatterjee S, Hawkins B J, et al. Caveolae are an essential component of the pathway for endothelial cell signaling associated with abrupt reduction of shear stress. BBA-Mol Cell Res, 2008, 1783: 1866–1875

    Google Scholar 

  30. Yamamoto K, Ando J. Blood flow sensing mechanism via calcium signaling in vascular endothelium (in Japanese). Yakugaku Zasshi, 2010, 130: 1407–1411

    Article  Google Scholar 

  31. Zeng Y, Sun H R, Yu C, et al. CXCR1 and CXCR2 are novel mechano-sensors mediating laminar shear stress-induced endothelial cell migration. Cytokine, 2011, 53: 42–51

    Article  Google Scholar 

  32. Chretien M L, Zhang M, Jackson M R, et al. Mechanotransduction by endothelial cells is locally generated, direction-dependent, and ligand-specific. J Cell Physiol, 2010, 224: 352–361

    Article  Google Scholar 

  33. Remuzzi A, Ene-Iordache B, Mosconi L, et al. Radial artery wall shear stress evaluation in patients with arteriovenous fistula for hemodialysis access. Biorheology, 2003, 40: 423–430

    Google Scholar 

  34. Li J W. Brilliant Achievemenst in Chinese Medicine (in Chinese). Beijing: Chinese Medicine Press of China, 1998

    Google Scholar 

  35. He Z J, Wu H Z. Photographic Collection of Chinese Medical Relics (in Chinese). Chengdu: Sichuan People’s Publisher, 2001

    Google Scholar 

  36. Zhu M. The Medical Classic of the Yellow Emperor (in Chinese). Beijing: Foreign Language Press, 2001

    Google Scholar 

  37. You Y, Liu W, Li Y, et al. Joint preventive effects of swimming and Shenlian extract on rat atherosclerosis. Clin Hemorheol Microcirc, 2011, 47: 187–198

    Google Scholar 

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Author information

Authors and Affiliations

  1. National Center for Nanoscience and Technology, Beijing, 100190, China

    Dong Han & FuLong Liao

  2. China Academy of Chinese Medical Sciences, Beijing, 100700, China

    FuLong Liao

Authors
  1. Dong Han
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  2. FuLong Liao
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Corresponding author

Correspondence to Dong Han.

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This article is published with open access at Springerlink.com

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Cite this article

Han, D., Liao, F. Chinese medicine, flowing blood, biomechanopharmacology and future preventive medicine. Chin. Sci. Bull. 57, 3541–3546 (2012). https://doi.org/10.1007/s11434-012-5226-8

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  • Received: 21 December 2011

  • Accepted: 23 April 2012

  • Published: 07 September 2012

  • Issue Date: September 2012

  • DOI: https://doi.org/10.1007/s11434-012-5226-8

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Keywords

  • Chinese medicine
  • Activating Blood Circulation to Remove Blood Stasis
  • flowing blood
  • biomechanopharmacology
  • preventive medicine
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