Abstract
A method for the two-step synthesis of magnetic composites with a γ-Fe2O3 core, silica inner layer and numerous gold nanoparticles supported on the surface of the silica (γ-Fe2O3/SiO2/Au) is described. First, thiol-functionalized γ-Fe2O3/SiO2 composites and gold colloids are prepared by modifying γ-Fe2O3/SiO2 composites with mercaptosilane and reduction of Au3+ to Au0 with citrate, respectively. Gold nanoparticles are then assembled on the surface of the thiol-functionalized γ-Fe2O3/SiO2 composites to form γFe2O3/SiO2/Au composites. The structure of the composite particles is confirmed by transmission electronic microscopy and powder X-ray diffraction. Immobilization studies with bovine serum albumin (BSA) demonstrate that the γ-Fe2O3/SiO2/Au composites can be used to immobilize BSA, making them useful for biomedical and biological applications.
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Li, Z., Peng, M., Jin, Y. et al. Synthesis of γ-Fe2O3/SiO2/Au magnetic composites for immobilization of bovine serum albumin. Chin. Sci. Bull. 56, 2911–2915 (2011). https://doi.org/10.1007/s11434-011-4672-z
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DOI: https://doi.org/10.1007/s11434-011-4672-z