Abstract
Catalytic acylation of nitriles with esters in the presence of 10 mol% NdNa8(OtBu)10(OH) is developed. The procedure is suitable for both enolizable and nonenolizable esters and affords β-ketonitriles in moderate to high yields. The heterometallic alkoxide cluster NdNa8(OtBu)10(OH) is structurally characterized by X-ray diffraction, and a mechanism for the production of β-ketonitriles using the cluster is proposed and verified.
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Liu, H., Li, L., Sheng, H. et al. Acylation of nitriles to β-ketonitriles catalyzed by a heterometallic alkoxide cluster of neodymium and sodium: NdNa8(OtBu)10(OH). Chin. Sci. Bull. 56, 1357–1360 (2011). https://doi.org/10.1007/s11434-011-4451-x
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DOI: https://doi.org/10.1007/s11434-011-4451-x