Abstract
To prevent the damage caused by DNA strand breaks, eukaryotic cells have evolved a series of highly conserved DNA repair mechanisms. The ubiquitously expressed acetyltransferase, Tip60, plays a central role in ATM (ataxia-telangiectasia mutated) activation which is involved in DNA repair. Recent work uncovered a new mechanism of ATM activation mediated by Tip60 and demonstrated that histone methylation, specifically, trimethylation of histone H3, is a key factor in the process. Here, we review the current understanding of how Tip60 is activated and how it activates ATM in response to DNA damage.
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Liu, Z., Sun, Y. Role of Tip60 tumor suppressor in DNA repair pathway. Chin. Sci. Bull. 56, 1212–1215 (2011). https://doi.org/10.1007/s11434-011-4433-z
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DOI: https://doi.org/10.1007/s11434-011-4433-z