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A parallel approach to direct resolution of albuterol

  • Letter
  • Organic Chemistry
  • Published:
Chinese Science Bulletin

Abstract

A library consisting of a series of O,O′-diaryzoyl-L-(-)-tartaric acids (2) was designed and synthesized. The substituent on the aromatic ring of 2 significantly affects the diastereomeric excess and efficiency of the resolution of racemic albuterol (1). Excellent resolving reagent 2a was selected for the resolution of rac-1 via the parallel approach. However, a family of three resolving reagents failed to improve the resolution efficiency of rac-1.

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Authors and Affiliations

  1. National Engineering Research Center of Chiral Drugs and Key Laboratory of Asymmetric Synthesis & Chirotechnology of Sichuan Province, Chengdu Institute of Organic Chemistry, Chinese Academy of Sciences, Chengdu, 610041, China

    QingLin Zhong, XiaoHua Peng, TongFei Wu, FangMin Fu, Xin Cui, Jin Zhu & JinGen Deng

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  1. QingLin Zhong
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  2. XiaoHua Peng
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  3. TongFei Wu
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  4. FangMin Fu
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  5. Xin Cui
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  6. Jin Zhu
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  7. JinGen Deng
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Corresponding author

Correspondence to JinGen Deng.

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Zhong, Q., Peng, X., Wu, T. et al. A parallel approach to direct resolution of albuterol. Chin. Sci. Bull. 55, 2814–2816 (2010). https://doi.org/10.1007/s11434-010-3156-x

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  • DOI: https://doi.org/10.1007/s11434-010-3156-x

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