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Chiral N-formyl amino alcohol as Lewis basic organocatalyst for enantioselective hydrosilylation of ketimines

  • Letters
  • Special Topic: Asymmetric Organocatalysis
  • Published:
Chinese Science Bulletin

Abstract

Easily accessible (1R,2S)-1,2-diphenyl-2-formamidoethanol has been developed as an effective Lewis base catalyst in the enantioselective hydrosilylation of ketimines, affording high isolated yields (up to 94%) and moderate to high enantioselectivities (up to 82% ee) for a broad range of ketimines.

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Authors and Affiliations

  1. Natural Products Research Center, Chengdu Institute of Biology, Chinese Academy of Sciences, Chengdu, 610041, China

    ZhouYu Wang, Li Zhou, XiaoXia Lu & Jian Sun

  2. Department of Pharmaceutics Engineering, Xihua University, Chengdu, 610039, China

    ZhouYu Wang

Authors
  1. ZhouYu Wang
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  2. Li Zhou
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  3. XiaoXia Lu
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  4. Jian Sun
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Corresponding author

Correspondence to Jian Sun.

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Wang, Z., Zhou, L., Lu, X. et al. Chiral N-formyl amino alcohol as Lewis basic organocatalyst for enantioselective hydrosilylation of ketimines. Chin. Sci. Bull. 55, 1726–1728 (2010). https://doi.org/10.1007/s11434-010-3123-6

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  • DOI: https://doi.org/10.1007/s11434-010-3123-6

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