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Asymmetric intramolecular oxa-Michael addition of activated α,β-unsaturated ketones by chiral N-triflyl phosphoramide

  • Letters
  • Special Topic: Asymmetric Organocatalysis
  • Published:
Chinese Science Bulletin

Abstract

Asymmetric intramolecular oxa-Michael addition of activated α,β-unsaturated ketones by chiral N-triflyl phosphoramide was realized. The flavanone products can be synthesized with excellent yields (50%–95%) and up to 74% ee.

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Authors and Affiliations

  1. State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai, 200032, China

    Zhen Feng, Mi Zeng, QingLong Xu & ShuLi You

Authors
  1. Zhen Feng
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  2. Mi Zeng
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  3. QingLong Xu
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  4. ShuLi You
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Corresponding author

Correspondence to ShuLi You.

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Feng, Z., Zeng, M., Xu, Q. et al. Asymmetric intramolecular oxa-Michael addition of activated α,β-unsaturated ketones by chiral N-triflyl phosphoramide. Chin. Sci. Bull. 55, 1723–1725 (2010). https://doi.org/10.1007/s11434-009-3735-x

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  • DOI: https://doi.org/10.1007/s11434-009-3735-x

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